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Retraction Note: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway

2016; Nature Portfolio; Volume: 19; Issue: 1 Linguagem: Inglês

10.1038/ncb3455

1476-4679

Shih-Ting Cha, Ching‐Ting Tan, Cheng-Chi Chang, Chia‐Yu Chu, Wei‐Jiunn Lee, Been-Zen Lin, Ming‐Tsan Lin, Min‐Liang Kuo,

Cancer Mechanisms and Therapy

In this Article, we reported that G9a promotes colorectal-cancer-initiating cell self-renewal and function by repressing Let-7b expression in a manner independent of its enzymatic activity, thereby activating K-RAS and β-catenin signalling.