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Dr. Dolittle and the making of the mitotic spindle

1999; Wiley; Volume: 21; Issue: 12 Linguagem: Inglês

10.1002/(sici)1521-1878(199912)22

1521-1878

Margarete M. S. Heck,

Microtubule and mitosis dynamics

BioEssaysVolume 21, Issue 12 p. 985-990 What the papers say Dr. Dolittle and the making of the mitotic spindle Margarete M. S. Heck, Margarete M. S. Heck margarete.heck@ed.ac.uk University of Edinburgh, Institute of Cell and Molecular Biology, Michael Swann Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.Search for more papers by this author Margarete M. S. Heck, Margarete M. S. Heck margarete.heck@ed.ac.uk University of Edinburgh, Institute of Cell and Molecular Biology, Michael Swann Building, The King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.Search for more papers by this author First published: 01 December 1999 https://doi.org/10.1002/(SICI)1521-1878(199912)22:1 3.0.CO;2-5Citations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The intrinsic polarity of microtubules within cells is exploited each time cells divide. Kinesins, microtubule-associated motor proteins, are required to execute the dramatic events of mitosis: bipolar spindle assembly, metaphase chromosome alignment, anaphase chromosome segregation, and separation of spindle poles prior to cytokinesis. Surprisingly, kinesin-related proteins have been found to move in either “plus-ward” or “minus-ward” directions along microtubules. Evidence from genetic analyses of simple eukaryotes and in vitro activity assays supports the notion that certain subfamilies of kinesin-related proteins provide antagonistic activities necessary to balance mitotic forces. A recent study by Sharp et al.(1) sheds further light on the subject by exploiting the genetics and cytology of the fruit fly embryo. BioEssays 21:985–990, 1999. © 1999 John Wiley & Sons, Inc. Citing Literature Volume21, Issue12December 1999Pages 985-990 RelatedInformation