Sickle-Cell Anemia: Molecular and Cellular Bases of Therapeutic Approaches
1978; Massachusetts Medical Society; Volume: 299; Issue: 15 Linguagem: Inglês
10.1056/nejm197810122991504
ISSN1533-4406
AutoresJurrien Dean, Alan N. Schechter,
Tópico(s)Hemoglobin structure and function
ResumoRed Blood CellsContained within the normal erythrocyte is a 5 mM solution of hemoglobin, constituting 97.5 per cent of the cytoplasmic protein by weight.121 The other 2.5 per cent is primarily made up of protein systems that can be considered to support and regulate the function of hemoglobin as well as maintain the integrity of the cell. These proteins provide energy to maintain the ionic composition and water content of the cell, supply a reducing potential to keep hemoglobin in the ferrous form and regulate appropriate levels of allosteric effectors, such as 2,3-DPG and hydrogen . . .
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