Ultrastructure of Trypanosoma cruzi in mouse brain
1968; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês
10.1016/0014-4894(68)90031-3
ISSN1090-2449
Autores Tópico(s)Trypanosoma species research and implications
ResumoAlbino mice were infected intracerebrally with Trypanosoma cruzi and killed after 7, 14, and 21 days. Fine sections of these animals' brains were studied with the electron microscope. Parasites were found in macrophages whose cytoplasm contained numerous bodies with membranous walls and of diverse sizes and shapes, with heterogeneous contents. This gave them the morphologic characteristics of lysosomes. These macrophages are accumulated usually in the proximity of blood vessels. Phagocytized parasites showed such ultrastructural changes as membrane irregularities that gave a scalloped appearance, evaginations of the perinuclear cistern, and modifications of the kinetoplast. These changes may be due to the lytic action of the enzymes of the macrophage lysosomes. Accumulations of macrophages with their lysosomes and phagocytized parasites characterize pathologically experimental Chagas' encephalitis in the white mouse.
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