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Aerosol Pentamidine

1988; American College of Physicians; Volume: 109; Issue: 11 Linguagem: Inglês

10.7326/0003-4819-109-11-852

1539-3704

Donald Armstrong, Elsa Bernard,

Immunodeficiency and Autoimmune Disorders

Editorials1 December 1988Aerosol PentamidineDonald Armstrong, MD, Edward Bernard, BADonald Armstrong, MD, Edward Bernard, BAAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-11-852 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAerosol pentamidine is widely used for prophylaxis and treatment of Pneumocystis carinii pneumonia, even though the Food and Drug Administration has not approved it for any indication. The widespread use arose because injectable pentamidine is approved for treating P. carinii pneumonia, and it became common practice to administer solutions using a nebulizer. Aerosol pentamidine is now the most frequently used experimental drug for disease related to the acquired immunodeficiency syndrome (AIDS).The first reports of efficacy in prophylaxis in rats appeared in 1985, and prophylactic use has grown, in spite of the paucity of well designed and supervised clinical trials....References1. Gajdusek D. Pneumocystis carinii as the cause of human disease: historical perspective and magnitude of the problem. Introductory remarks. National Cancer Institute Monograph 43, October 1976. Google Scholar2. GottliebSchroffSchanker MRH. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N Engl J Med. 1981;305:1425-31. CrossrefMedlineGoogle Scholar3. MasurMichelisGreene HMJ. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med. 1981;305:1431-8. CrossrefMedlineGoogle Scholar4. SiegalLopezHammer FCG. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981;305:1439-44. CrossrefMedlineGoogle Scholar5. ArmstrongGoldDryjanski DJJ. Treatment of infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:738-43. LinkGoogle Scholar6. WhartonColemanWofsy JDC. Trimethoprim-sulfamethoxazole or pentamidine for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective randomized trial. Ann Intern Med. 1986;105:37-44. LinkGoogle Scholar7. LeoungMillsHopewellHughesWofsy GJPWC. Dapsone-trimethoprim for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Ann Intern Med. 1986;105:45-8. LinkGoogle Scholar8. AllegraChabnerTuazon CBC. Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1987;317:978-85. CrossrefMedlineGoogle Scholar9. BrennesselGoldstein DJ. Eflomithine hydrochloride (DFMO) in the therapy (rx) of Pneumocystis carinii pneumonia (PCP) in AIDS [Abstract]. Second International Conference on AIDS, Paris, France, June 23-25, 1986. Google Scholar10. HughesKuhnChaudhary WSS. Successful chemoprophylaxis for Pneumocystis carinii pneumonia. N Engl J Med. 1977;297:1419-26. CrossrefMedlineGoogle Scholar11. FischlDickinsonLa Voie MGL. Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocys-tis carinii pneumonia in AIDS. JAMA. 1988;259:1185-9. CrossrefMedlineGoogle Scholar12. BernardDonnellyKoo EHH. Aerosol administration improved delivery of pentamidine to the lungs [Abstract]. In: Program and Abstracts of the 25th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, American Society for Microbiology, 1985:193. Google Scholar13. DebsBlumenfeldBrunette RWE. Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1987;31:37-41. CrossrefMedlineGoogle Scholar14. GirardBrun-PascandFarinottiTamisierKernbaum PMRSS. Pentamidine aerosol in prophylaxis and treatment of murine Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1987;31:978-81. CrossrefMedlineGoogle Scholar15. BernardSchmittLifton EHA. Prevention of Pneumocystis carinii pneumonia with aerosol pentamidine [Abstract]. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988. Google Scholar16. MontgomeryDebsLuce ARJ. Aerosolised pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet. 1987;2:480-3. CrossrefMedlineGoogle Scholar17. ConteHollanderGolden JHJ. Inhaled or reduced-dose intravenous pentamidine for Pneumocystis carinii pneumonia. Ann Intern Med. 1987;107:495-8. LinkGoogle Scholar18. Godfrey-FaussettMillerSemple PRS. Nebulized pentamidine [Letter]. Lancet. 1988;1:645-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memorial Sloan-Kettering Cancer Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitroPentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunctionRespiratory Diseases in PregnancySelf-assessment: inflammatory lesionsPneumonia During PregnancyPulmonary delivery of therapeutic peptides and proteinsUtility of Inhaled Pentamidine Prophylaxis in Lung Transplant RecipientsPneumocystis carinii pneumonia in cancer patientsPneumocystis carinii of the OrbitTrimetrexate for Pneumocystis Carinii Pneumonia in Patients with AidsChemotherapeutic Targets in Pneumocystis cariniiPneumocystosisDisseminated pneumocystis carinii infection in AIDS.A Multicenter Study of Pneumocystis ChoroidopathyAerosol Pentamidine for Secondary Prophylaxis of AIDS-related Pneumocystis carinii Pneumonia A Randomized, Placebo-Controlled StudyJulio S. 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Bernard, BA, Dorothy A. White, MDCompliance and laboratory data predict relapse rate of pneumocystis carinii pneumonia during prophylaxis with aerosol pentamidineAIDS and the lung. 7. Treatment of lung disease in patients with the acquired immune deficiency syndrome.Pneumocystis Carinii Pneumonia ProphylaxisAerosolized Pentamidine for Pneumocystis carinii PneumoniaPneumocystis Hepatitis and Choroiditis Despite Successful Aerosolized Pentamidine Pulmonary ProphylaxisNew Uses for Old DrugsEpidemiology of human immunodeficiency virus infection and acquired immunodeficiency syndromePREVENTION OF PNEUMOCYSTIS CARINII PNEUMONIA RELAPSE BY PENTAMIDINE AEROSOL IN ZIDOVUDINE-TREATED AIDS PATIENTSAerosolized Pentamidine and Pneumocystis carinii PneumoniaA. Bruce Montgomery, MD, David W. Feigal, MD, John M. Luce, MD, Philip C. Hopewell, MD, Daniel F. Hoth, MD, Maureen W. Myers, PhD, Judith E. Feinberg, MD, John Mills, MD, Fred R. Sattler, MDAerosolized PentamidineStephen M. Picea, MDAerosolized PentamidineEran Bellin, MD 1 December 1988Volume 109, Issue 11Page: 852-854KeywordsAIDSClinical trial reportingDrugsFood and Drug AdministrationPneumocystis carinii pneumoniaPneumoniaProphylaxis Issue Published: 1 December 1988 PDF DownloadLoading ...