Rational Design of Evolutionarily Stable Microbial Kill Switches
2018; Elsevier BV; Volume: 72; Issue: 2 Linguagem: Inglês
10.1016/j.molcel.2018.10.002
ISSN1097-4164
AutoresFinn Stirling, Lisa Bitzan, Samuel O’Keefe, Elizabeth Redfield, John W. K. Oliver, Jeffrey C. Way, Pamela A. Silver,
Tópico(s)CRISPR and Genetic Engineering
Resumo(Molecular Cell 68, 686–697.e1–e3; November 16, 2017) In the originally published version of this article, there was an error in Figure S3. The sequence in the figure was incorrect due to a copying error in the GenBank file that resulted in a 42 base pair/14 amino acid insertion into the open reading frame of CcdB. This error has since been fixed, and the correct Figure S3 now appears online with the article. Both the corrected and the original versions can be seen below; bases between 759 and 801 (inclusive) have been removed in the corrected version. The authors apologize for any confusion.Figure S3(original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Rational Design of Evolutionarily Stable Microbial Kill SwitchesStirling et al.Molecular CellNovember 16, 2017In BriefBiocontainment of microorganisms is becoming an increasingly relevant issue as functional uses for transgenic organisms outside of a controlled laboratory become readily available. By limiting bacterial growth with evolutionarily stable kill switches, it is possible to impart some level of control over which environments a transgenic organism is viable in. Full-Text PDF Open Archive
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