Enantioselective Synthesis of P‐Stereogenic Phosphinates and Phosphine Oxides by Molybdenum‐Catalyzed Asymmetric Ring‐Closing Metathesis
2008; Wiley; Volume: 121; Issue: 4 Linguagem: Inglês
10.1002/ange.200805066
ISSN1521-3757
AutoresJames Harvey, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda, Véronique Gouverneur,
Tópico(s)Chemical Synthesis and Analysis
ResumoAngewandte ChemieVolume 121, Issue 4 p. 776-780 Zuschrift Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis† James Stephen Harvey, James Stephen Harvey Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorSteven J. Malcolmson, Steven J. Malcolmson Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorKatherine S. Dunne Dr., Katherine S. Dunne Dr. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorSimon J. Meek Dr., Simon J. Meek Dr. Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorAmber L. Thompson Dr., Amber L. Thompson Dr. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorRichard R. Schrock Prof., Richard R. Schrock Prof. Department of Chemistry, Massachusetts Institute of Technology (USA)Search for more papers by this authorAmir H. Hoveyda Prof., Amir H. Hoveyda Prof. [email protected] Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorVéronique Gouverneur Prof., Véronique Gouverneur Prof. [email protected] Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this author James Stephen Harvey, James Stephen Harvey Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorSteven J. Malcolmson, Steven J. Malcolmson Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorKatherine S. Dunne Dr., Katherine S. Dunne Dr. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorSimon J. Meek Dr., Simon J. Meek Dr. Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorAmber L. Thompson Dr., Amber L. Thompson Dr. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this authorRichard R. Schrock Prof., Richard R. Schrock Prof. Department of Chemistry, Massachusetts Institute of Technology (USA)Search for more papers by this authorAmir H. Hoveyda Prof., Amir H. Hoveyda Prof. [email protected] Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA), Fax: (+1) 617-552-1442Search for more papers by this authorVéronique Gouverneur Prof., Véronique Gouverneur Prof. [email protected] Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK), Fax: (+44) 1865-275-644Search for more papers by this author First published: 05 January 2009 https://doi.org/10.1002/ange.200805066Citations: 24 † This research was financially supported by the EPSRC (DTA Award to J.S.H.), the John Fell Fund (062/214), and by the United States National Institutes of Health (GM-59426). Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Der erste katalytische Zugang zu den Titelverbindungen durch asymmetrische Ringschlussmetathese wird beschrieben. Die bemerkenswerte Umkehrung der Enantioselektivität bei einem Wechsel des achiralen Imidoliganden des chiralen Molybdänkatalysators (siehe Schema) unterstreicht die Bedeutung von achiralen und chiralen Liganden beim Katalysatordesign. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". 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