ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells
2017; Elsevier BV; Volume: 21; Issue: 3 Linguagem: Inglês
10.1016/j.stem.2017.08.008
ISSN1934-5909
AutoresNicole I. Park, Paul Guilhamon, Kinjal Desai, Rochelle F. McAdam, Ellen Langille, Madlen O’Connor, Xiaoyang Lan, Heather Whetstone, Fiona J. Coutinho, Robert J. Vanner, Erick K. M. Ling, Panagiotis Prinos, Lilian Lee, Hayden Selvadurai, Gurnit Atwal, Michelle Kushida, Ian D. Clarke, Véronique Voisin, Michael D. Cusimano, Mark Bernstein, Sunit Das, Gary D. Bader, C.H. Arrowsmith, Stéphane Angers, Xi Huang, Mathieu Lupien, Peter B. Dirks,
Tópico(s)Circular RNAs in diseases
Resumo(Cell Stem Cell 21, 209–224; August 3, 2017) In our original paper, we mistakenly incorporated incorrect catalog information for the TUBB3 antibody into the Key Resources Table. The correct information is as follows: Resource, Anti-TUBB3 antibody (clone TU-20); Source, Millipore; Identifier, Cat#MAB1637; RRID: AB_2210524. We also mistakenly listed incorrect gRNA targeting sequences for ASCL1 in Table S7. The correct information is as follows: gRNA targeting sequence ASCL1 #1, GGAGCACGTCCCCAACGGCGCGG and gRNA targeting sequence ASCL1 #2, GCAAAGAAACAGGCTGCGGGCGG. This information has now been corrected in our article’s Key Resources Table and Table S7 online. We apologize for the oversight. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem CellsPark et al.Cell Stem CellJuly 13, 2017In BriefGlioblastoma is characterized by a block in cellular differentiation. Park et al. identify a subset of glioblastoma stem cells (GSCs) that express high levels of the proneural transcription factor ASCL1 and differentiate in response to Notch inhibition, effectively abrogating their stemness properties and tumorigenic potential. Full-Text PDF Open Archive
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