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Effects of chronic hypobaric hypoxia on blood oxygen binding in pigeons

1997; Wiley; Volume: 277; Issue: 4 Linguagem: Inglês

10.1002/(sici)1097-010x(19970301)277

1097-010X

Leigh A. Maginniss, Marvin H. Bernstein, Mark A. Deitch, Berry Pinshow,

Cardiovascular Disease and Adiposity

Journal of Experimental ZoologyVolume 277, Issue 4 p. 293-300 Comparative Physiology and BiochemistryFull Access Effects of chronic hypobaric hypoxia on blood oxygen binding in pigeons Leigh A. Maginniss, Corresponding Author Leigh A. Maginniss Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912Department of Biological Sciences, DePaul University, 1036 West Belden Avenue, Chicago, IL 60614===Search for more papers by this authorMarvin H. Bernstein, Marvin H. Bernstein Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003Search for more papers by this authorMark A. Deitch, Mark A. Deitch Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912Search for more papers by this authorBerry Pinshow, Berry Pinshow Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003Search for more papers by this author Leigh A. Maginniss, Corresponding Author Leigh A. Maginniss Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912Department of Biological Sciences, DePaul University, 1036 West Belden Avenue, Chicago, IL 60614===Search for more papers by this authorMarvin H. Bernstein, Marvin H. Bernstein Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003Search for more papers by this authorMark A. Deitch, Mark A. Deitch Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912Search for more papers by this authorBerry Pinshow, Berry Pinshow Department of Biology, New Mexico State University, Las Cruces, New Mexico 88003Search for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-010X(19970301)277:4 3.0.CO;2-KCitations: 13AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Effects of chronic hypobaric hypoxia on blood O2 transport were studied using two groups of domestic pigeons (Columba livia). High-altitude (HA) birds were acclimated for 6 wk at 7 km simulated altitude (308 Torr, 25°C); sea-level (SL) pigeons were maintained for 5–6 wk at 758 Torr (25°C). Whole blood O2 equilibrium curves (O2ECs) were generated for HA and SL pigeons at 37°C and 41°C using thin film techniques. At pH 7.50 and 41°C, half-saturation PO2s (P50) for HA and SL birds were 32.9 ± 1.4 (6); (mean ± S.E.M. [N]) and 35.6 ± 0.6 (6) Torr, respectively. At pH 7.56 and 37°C, the corresponding P50s were 26.5 ± 1.8 (4) and 29.0 ± 0.6 (5) Torr, respectively. HA and SL pigeons exhibited similar Hb-O2 temperature coefficients (ΔH = −9.8 to −10.6 kcal/mole O2) and CO2 (Bohr slopes (Δlog P50/ΔpH = −.43 to −.44 at 37°C; −.41 at 41°C). Hill's n increased with increasing saturation for both animal groups at 37°C and 41°C. Hypoxic acclimation elicited a significant increase in O2 capacity; %Hct and [Hb] increased by 38% and 43%, respectively. Chronic hypoxia had no effect on isohemoglobin composition; both groups exhibited two isoHb fractions in a 9:1 molar ratio. At PaO2 = 30 Torr, calculated in vivo CaO2 for HA (39.2°C, pH 7.53) and SL (41°C, pH 7.50) birds were 14.2 vol % and 7.6 vol %, respectively. Results suggest that altitude tolerance of pigeons is enhanced by the increased blood O2 capacity and the effect of hypoxia-induced hypothermia on Hb-O2 affinity. J. Exp. Zool. 277:293–300, 1997. © 1997 Wiley-Liss, Inc. Literature Cited Baumann, F. H., and R. Baumann (1977) A comparative study of the respiratory properties of bird blood. Respir. Physiol., 31: 333–343. 10.1016/0034-5687(77)90076-7 CASPubMedWeb of Science®Google Scholar Bernstein, M. H. (1989) Respiration by birds at high altitude and in flight. 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