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Stochastic Detection of Monovalent and Bivalent Protein–Ligand Interactions

2004; Wiley; Volume: 116; Issue: 7 Linguagem: Inglês

10.1002/ange.200352614

1521-3757

Stefan Howorka, Joonwoo Nam, Hagan Bayley, Daniel Kahne,

DNA and Nucleic Acid Chemistry

Angewandte ChemieVolume 116, Issue 7 p. 860-864 Zuschrift Stochastic Detection of Monovalent and Bivalent Protein–Ligand Interactions† Stefan Howorka Dr., Stefan Howorka Dr. howorka@medicine.tamu.edu The Texas A&M University System Health Science Center, Department of Medical Biochemistry & Genetics, 440 Reynolds Medical Building, College Station, TX 77843-1114, USA Present address: Upper Austrian Research GmbH, Scharitzerstrasse 6–8/4, A-4020, Austria, Fax: (+43) 732-6060-7930Search for more papers by this authorJoonwoo Nam, Joonwoo Nam Department of Chemistry, Princeton University, Princeton, NJ 08544, USASearch for more papers by this authorHagan Bayley Prof., Hagan Bayley Prof. The Texas A&M University System Health Science Center, Department of Medical Biochemistry & Genetics, 440 Reynolds Medical Building, College Station, TX 77843-1114, USA Present addresses: Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, and, Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, England, UKSearch for more papers by this authorDaniel Kahne Prof., Daniel Kahne Prof. Department of Chemistry, Princeton University, Princeton, NJ 08544, USASearch for more papers by this author Stefan Howorka Dr., Stefan Howorka Dr. howorka@medicine.tamu.edu The Texas A&M University System Health Science Center, Department of Medical Biochemistry & Genetics, 440 Reynolds Medical Building, College Station, TX 77843-1114, USA Present address: Upper Austrian Research GmbH, Scharitzerstrasse 6–8/4, A-4020, Austria, Fax: (+43) 732-6060-7930Search for more papers by this authorJoonwoo Nam, Joonwoo Nam Department of Chemistry, Princeton University, Princeton, NJ 08544, USASearch for more papers by this authorHagan Bayley Prof., Hagan Bayley Prof. The Texas A&M University System Health Science Center, Department of Medical Biochemistry & Genetics, 440 Reynolds Medical Building, College Station, TX 77843-1114, USA Present addresses: Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, and, Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, England, UKSearch for more papers by this authorDaniel Kahne Prof., Daniel Kahne Prof. Department of Chemistry, Princeton University, Princeton, NJ 08544, USASearch for more papers by this author First published: 02 February 2004 https://doi.org/10.1002/ange.200352614Citations: 14 † This work was supported by the U.S. Department of Energy, the DoD Tri-Service Technology Program, the National Institutes of Health, the Office of Naval Research (Multidisciplinary University Research Initiative 1999), and the Texas Advanced Technology Program. H.B. is the holder of a Royal Society-Wolfson Research Merit Award. S.H. held fellowships from the Austrian Science Foundation (Fonds zur Förderung der wissenschaftlichen Forschung) and the Max-Kade Foundation. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Valenzstudien an Einzelmolekülen: Die Bindungskinetik eines tetravalenten Lectins kann auf Einzelmolekülniveau unter Verwendung von Proteinporen untersucht werden, die mit bis zu sieben Kohlenhydrat-Liganden modifiziert wurden. Die Bindung des Lectins an die Pore (siehe Molekülmodell) erzeugt kurze und lange reversible Blockaden des Einzelkanalstroms, die als monovalente bzw. divalente Bindungsereignisse interpretiert werden. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z52614_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume116, Issue7February 6, 2004Pages 860-864 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation