Artigo Acesso aberto Revisado por pares

Self‐Healing Microencapsulation of Biomacromolecules without Organic Solvents

2012; Wiley; Volume: 124; Issue: 43 Linguagem: Inglês

10.1002/ange.201206387

ISSN

1521-3757

Autores

Samuel E. Reinhold, Kashappa Goud H. Desai, Li Zhang, Karl Olsen, Steven P. Schwendeman,

Tópico(s)

Electrohydrodynamics and Fluid Dynamics

Resumo

Angewandte ChemieVolume 124, Issue 43 p. 10958-10961 Zuschrift Self-Healing Microencapsulation of Biomacromolecules without Organic Solvents† Dr. Samuel E. Reinhold, Dr. Samuel E. Reinhold Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) Present address: Upsher-Smith Laboratories, Inc. 6701 Evenstad Drive, Maple Grove, MN 55369 (USA) These authors contributed equally to this research.Search for more papers by this authorDr. Kashappa-Goud H. Desai, Dr. Kashappa-Goud H. Desai Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) These authors contributed equally to this research.Search for more papers by this authorDr. Li Zhang, Dr. Li Zhang Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) Present address: Teva Parenteral Medicines, 19 Hughes, Irvine, CA 92618 (USA)Search for more papers by this authorKarl F. Olsen, Karl F. Olsen Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this authorProf. Steven P. Schwendeman, Corresponding Author Prof. Steven P. Schwendeman [email protected] Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this author Dr. Samuel E. Reinhold, Dr. Samuel E. Reinhold Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) Present address: Upsher-Smith Laboratories, Inc. 6701 Evenstad Drive, Maple Grove, MN 55369 (USA) These authors contributed equally to this research.Search for more papers by this authorDr. Kashappa-Goud H. Desai, Dr. Kashappa-Goud H. Desai Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) These authors contributed equally to this research.Search for more papers by this authorDr. Li Zhang, Dr. Li Zhang Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA) Present address: Teva Parenteral Medicines, 19 Hughes, Irvine, CA 92618 (USA)Search for more papers by this authorKarl F. Olsen, Karl F. Olsen Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this authorProf. Steven P. Schwendeman, Corresponding Author Prof. Steven P. Schwendeman [email protected] Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this author First published: 26 September 2012 https://doi.org/10.1002/ange.201206387Citations: 5 † This study was funded by NIH R01 HL 68345 and R21 EB 08873. We greatly appreciate the help of Shobha Churi and Dr. Manjunatha (JSS University, Mysore, India) in the procurement of the sample of tetanus toxoid. We are grateful to Dr. Rajesh Gupta, US Food and Drug Administration, for his assistance with ELISA and for providing the sample of equine tetanus antitoxin. We also thank Dr. Heather W. Collins, University of Pennsylvania School of Medicine, for conducting radioimmunoassays. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Alle Ausgänge verschließen! Die konventionelle Verkapselung von Biomakromolekülen in Poly(milchsäure-co-glycolsäure) (PLGA) erfordert mehrere Verfahrensschritte, die das Molekül schädigen können. Dagegen verläuft eine selbstheilungsbasierte Verkapselung in PLGA ohne Beschädigung des Proteins, was dessen Stabilisierung und langsame Freisetzung ermöglicht. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". 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