Analysis of Genetic Linkage
2014; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-801238-3.05482-9
Autores Tópico(s)Bioinformatics and Genomic Networks
ResumoLinkage analysis is a well-established statistical method for mapping heritable trait genes to their chromosome locations. Genome-wide markers are tested in pedigrees segregating a trait. The statistical method of linkage analysis combines these data to identify chromosome regions likely to harbor genes for the trait. Parametric linkage analysis is used for traits with a Mendelian form of inheritance. LOD scores and recombination fractions are used to test the gene locations. Model-free linkage analysis is used for complex traits, where the model of inheritance is not known. Linkage analysis can be used to map genes for both binary and quantitative traits.
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