Portal de Periódicos da CAPES

Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase

2012; Wiley; Volume: 124; Issue: 40 Linguagem: Inglês

10.1002/ange.201204038

1521-3757

Hao‐Wei Shih, Yi‐Fan Chang, Wei‐Jing Li, Fan‐Chun Meng, Chia‐Ying Huang, Che Ma, Ting-Jen Rachel Cheng, Chi‐Huey Wong, Wei‐Chieh Cheng,

Bacterial Genetics and Biotechnology

Gegen die Wand: Lipid-II-Analoga mit modifizierten Peptideinheiten wurden als Substrate der bakteriellen Transglycosylase getestet. D-Lactat und L-Alanin an den ersten beiden Positionen (siehe Schema), und insbesondere deren Methylgruppen, sind essenziell für die Substratbindung. Dieses Ergebnis ist bedeutsam für die Entwicklung von Antibiotika als Hemmer der Zellwand-Biosynthese. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.