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Anthramycin

1971; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-65141-0_5

2197-8484

Susan Band Horwitz,

Chronic Myeloid Leukemia Treatments

In 1963, it was reported that the fermentation broth of Streptomyces refuineus var. thermotolerans contained a component referred to as ‘refuin’ which had activity against experimental tumors (Tendler and Korman, 1963). The active component of this broth was identified as anthramycin [Leimgruber, Stefanovic, Schenker, Karr and Berger, 1965 (2)] an antibiotic subsequently found to possess antitumor, anti¬microbial, amebicidal and chemosterilant properties. The following paper reviews the biochemical pharmacology of anthramycin with particular reference to its interaction with DNA.