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Molecular mechanisms of tazarotene action in psoriasis

1997; Elsevier BV; Volume: 37; Issue: 2 Linguagem: Inglês

10.1016/s0190-9622(97)70412-2

1097-6787

Madeleine Duvic, Sunil Nagpal, Arisa Asano, Roshantha A.S. Chandraratna,

Estrogen and related hormone effects

Psoriasis is a chronic immune-mediated disease that is characterized by the hyperproliferation and abnormal differentiation of keratinocytes and by inflammation. The epidermal changes associated with psoriasis may be due to the infiltration of inflammatory T lymphocytes and the release of cytokines in response to antigenic stimulation. Tazarotene is a retinoic acid receptor-specific retinoid with demonstrated efficacy in the topical treatment of psoriasis. Tazarotene downregulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. The drug also upregulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. The effect of tazarotene on these markers is probably a direct effect on gene expression rather than an indirect effect associated with disease improvement. (J Am Acad Dermatol 1997; 37:S18–S24.)