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Meet the First Authors

2018; Lippincott Williams & Wilkins; Volume: 123; Issue: 8 Linguagem: Inglês

10.1161/res.0000000000000230

1524-4571

Xiaolu Pan, Leonne E. Philippen,

CRISPR and Genetic Engineering

HomeCirculation ResearchVol. 123, No. 8Meet the First Authors Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBMeet the First Authors Originally published27 Sep 2018https://doi.org/10.1161/RES.0000000000000230Circulation Research. 2018;123:926–927is related toIn Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular TachycardiaSerum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery Diseaseis related toMechanisms of Connexin-Related LymphedemaEffect of Intracoronary Metformin on Myocardial Infarct Size in SwineGenome Editing Cures CPVT in Mice (p 953)Download figureDownload PowerPointDr Xiaolu Pan is a research scientist at the Baylor College of Medicine, under the supervision of Dr Xander Wehrens. She earned her MD from Guizhou Medical University in China in 2012. She then joined the University of Texas MD Anderson Cancer Center for basic research training, earning an MSc degree in Genetics and Cancer Biology in 2015. Her thesis research under the supervision of Dr Xin Lu and Dr Ronald DePinho led to the identification of prostate cancer–driver genes using high-throughput functional genomics. This research was published in Cancer Research. Driven by an interest in applying genetics to personalized medicine, Dr Pan transitioned to cardiovascular research in Xander Wehrens’s lab to focus on gene therapy of inherited arrhythmia syndromes using the CRISPR/Cas9 system. Specifically, Dr Pan is now focused on developing new CRISPR/Cas9-based approaches for mechanistic studies of heart disease and as a novel treatment strategy for catecholaminergic polymorphic ventricular tachycardia. Apart from work, Xiaolu enjoys hiking and rock climbing to be close to nature.Genome Editing Cures CPVT in Mice (p 953)Download figureDownload PowerPointDr Leonne Philippen began her academic career at Utrecht University (MSc, biomedical sciences, summa cum laude) and continued at Maastricht University in the Netherlands (PhD, Molecular Biology), where she studied the role of noncoding RNAs in eccentric cardiac remodeling and heart failure with Dr Leon de Windt. She followed her passion for cardiovascular research by joining Xander Wehrens’s lab at Baylor College of Medicine in Houston, TX, in 2014, where she performed research using the CRISPR/Cas9 tool to treat catecholaminergic polymorphic ventricular tachycardia, described in this article. After moving all the way to Houston to then run into her (also Dutch) husband, she not only changed her last name (now van Poelgeest) but also changed her career. She is currently a management consultant at McKinsey & Company, leaving the academic world behind to broaden her skillset in industry. Outside work, she enjoys spending time with her husband and their two cats, traveling to places with beautiful nature, and she loves to drive high-performance cars and racing motorcycles.Mechanisms of Connexin-Related Lymphedema (p 964)Download figureDownload PowerPointDr Jorge A. Castorena-Gonzalez is a postdoctoral fellow working for Dr Michael J. Davis at the Department of Medical Pharmacology and Physiology of the University of Missouri. Jorge earned his BSc and MSc in Physics at the University of Guanajuato in Leon, Mexico. In 2014, he earned his PhD in Bioengineering from the University of Missouri (mentors, Dr Luis A. Martinez-Lemus and Dr Luis Polo-Parada). Using transgenic mouse models and optogenetics, Jorge’s present work aims to study lymphatic contractile dysfunction. This involves the understanding of the intercellular communication in the lymphatic wall and characterizing the underlying electrical and calcium signals. As a nuclear physicist, Jorge worked in the world’s largest particle accelerators (ie, CERN and Fermilab). Jorge is now interested in applying his knowledge of physics and vascular physiology to pursue a career as an independent investigator. His research will focus on determining the role of the lymphatic endothelium in regulating contractile function, studying lymphatic dysfunction associated with obesity and diabetes, and developing new methods and technologies for the assessment and treatment of lymphatic dysfunction in humans. Outside of science, Jorge enjoys going on road trips with his wife, Lauren, and their dog, Barrett, video-calling with his family in Mexico, playing fútbol, weight-lifting, cooking Mexican food, and playing the drums.Intracoronary Metformin and Infarct Size in Swine (p 986)Download figureDownload PowerPointGeorge Techiryan is an MD/PhD student at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. He is currently working towards completion of his PhD research in the Division of Cardiovascular Medicine under the mentorship of Dr John M. Canty Jr. George completed his undergraduate training at UCLA and received a BS degree in Physiological Science in 2012. His research is focused on the evaluation of novel cardioprotective therapies via rigorous testing in experimental large animal models of acute myocardial infarction. In pursuing this goal, he has developed a strong appreciation for the important role that well-designed preclinical experiments can play in the clinical translation of new treatments, even when they produce negative results! Outside of the laboratory, George is a serial do-it-yourself hobbyist who enjoys learning the detailed nuances of various activities. Some of his favorite pastimes include remodeling his home with his dad, culturing homemade yogurt, and—notably—jerry rigging a “sailboat” out of an inflatable raft and PVC pipes only to watch it collapse when confronted by a mild wind.Bioavailable Vitamin D and Mortality (p 996)Download figureDownload PowerPointDr Chao Yu earned his MD from Anhui Medical University in 2004. Afterwards, he interned at the 3rd Affiliated Hospital of Sun Yat-sen University and later worked as an attending physician. From 2012 onwards, he has been a PhD student in the Department of Nutrition, School of Public Health, Sun Yat-sen University, under the supervision of Dr Wenhua Ling. His current research focuses on vitamin D and outcomes of coronary artery disease and nonalcoholic fatty liver disease. Outside of the lab, he enjoys playing soccer, outdoor activities, and spending time with his family.Bioavailable Vitamin D and Mortality (p 996)Download figureDownload PowerPointHongliang Xue is a PhD candidate at the Department of Nutrition, School of Public Health, Sun Yat-sen University, under the supervision of Dr Wenhua Ling. He earned his BS from Wuhan University, China. His main research interests are nutrients, intestinal microflora, and metabolic disease. He recently collaborated on a manuscript with friend and colleague, Dr Chao Yu, at Sun Yat-sen University. In his spare time, he enjoys reading, running, and playing basketball. Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesIn Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular TachycardiaXiaolu Pan, et al. Circulation Research. 2018;123:953-963Serum Bioavailable and Free 25-Hydroxyvitamin D Levels, but Not Its Total Level, Are Associated With the Risk of Mortality in Patients With Coronary Artery DiseaseChao Yu, et al. Circulation Research. 2018;123:996-1007Mechanisms of Connexin-Related LymphedemaJorge A. Castorena-Gonzalez, et al. Circulation Research. 2018;123:964-985Effect of Intracoronary Metformin on Myocardial Infarct Size in SwineGeorge Techiryan, et al. Circulation Research. 2018;123:986-995 September 28, 2018Vol 123, Issue 8 Advertisement Article InformationMetrics © 2018 American Heart Association, Inc.https://doi.org/10.1161/RES.0000000000000230PMID: 30355045 Originally publishedSeptember 27, 2018 PDF download Advertisement