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Efficacy of pyrimethamine for the prevention of donor-acquired Toxoplasma gondii infection in heart and heart-lung transplant patients

1992; Springer Science+Business Media; Volume: 5; Issue: 4 Linguagem: Inglês

10.1111/j.1432-2277.1992.tb01745.x

1432-2277

Tim Wreghitt, Jeffrey J. Gray, P Pavel, A H Balfour, Alberto Fabbri, L. Sharpies, J. Wallwork,

Pneumocystis jirovecii pneumonia detection and treatment

Transplant InternationalVolume 5, Issue 4 p. 197-200 Efficacy of pyrimethamine for the prevention of donor-acquired Toxoplasma gondii infection in heart and heart-lung transplant patients T.G. Wreghitt, Corresponding Author T.G. Wreghitt Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB22QQ, UKCorrespondence to: T. G. WreghittSearch for more papers by this authorJ.J. Gray, J.J. Gray Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB22QQ, UKSearch for more papers by this authorP. Pavel, P. Pavel The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorA. Balfour, A. Balfour Toxoplasma Reference Laboratory, Public Health Laboratory, Bridle Path, York Road, Leeds LS15 7TR, UKSearch for more papers by this authorA. Fabbri, A. Fabbri The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorL. D. Sharpies, L. D. Sharpies The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorJ. Wallwork, J. Wallwork The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this author T.G. Wreghitt, Corresponding Author T.G. Wreghitt Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB22QQ, UKCorrespondence to: T. G. WreghittSearch for more papers by this authorJ.J. Gray, J.J. Gray Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB22QQ, UKSearch for more papers by this authorP. Pavel, P. Pavel The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorA. Balfour, A. Balfour Toxoplasma Reference Laboratory, Public Health Laboratory, Bridle Path, York Road, Leeds LS15 7TR, UKSearch for more papers by this authorA. Fabbri, A. Fabbri The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorL. D. Sharpies, L. D. Sharpies The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this authorJ. Wallwork, J. Wallwork The Transplant Unit, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, UKSearch for more papers by this author First published: July 1992 https://doi.org/10.1111/j.1432-2277.1992.tb01745.xCitations: 50AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Abstract. Seven (11%) of the first 65 patients who received heart transplants at Papworth Hospital were mismatched for Toxoplasma gondii. Of these, four (57%) experienced T. gondii infection and two died. The remaining two had severe symptoms and received anti-T-gondii chemotherapy for a year after transplantation. In an attempt to reduce the impact of donor-acquired T. gondii in our heart transplant recipients, we decided in April 1984 to give prophylactic pyrimethamine to all T. gondii-mis-matched patients. In this study, 7 years later, we review the efficacy of this policy. Five of 37 (14%) patients given prophylactic pyrimethamine acquired T. gondii infection; only one was symptomatic, and none died. This compares with 100% symptomatic infection in the pre-1984 patients, who did not receive prophylactic pyrimethamine. 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Citing Literature Volume5, Issue4July 1992Pages 197-200 ReferencesRelatedInformation