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A clinical trial with culturally tailored video to increase participation of African Americans in cancer clinical trials.

2011; Lippincott Williams & Wilkins; Volume: 29; Issue: 15_suppl Linguagem: Inglês

10.1200/jco.2011.29.15_suppl.6075

1527-7755

Dorothy Banda, Mario Viligius Primus Hangga Mete, R. Kapoor, S. M. Swain,

Social Media in Health Education

6075 Background: There is a need to develop patient-level interventions to change attitudes and increase African American (AA) participation in cancer clinical trials (CT). This pilot study tests the efficacy of a 15 minute narrative-based video which we created in the first such intervention in AA patients. Methods: This single group, pre/post-test, mixed methods study enrolled cancer patients in active treatment at a large urban cancer institute. Eligible patients were self-identified AA, ≥ 21 years, and never participated in a CT. The primary outcome was self-reported likelihood to enroll in a therapeutic CT. Participants were interviewed at baseline using an instrument developed specifically to assess attitudes on six trial barriers. An immediate post-test was administered following the video. McNemar’s test for matched pairs was used to assess the change in likelihood to enroll in a CT. Stuart-Maxwell marginal homogeneity test for matched pairs with multi-category outcomes was used to evaluate which attitudes were impacted by the intervention. Multivariate logistic regression analysis adjusted for matching baseline variables was used to assess the effect of demographic variables independently of the intervention. Results: Patients enrolled October 2010- January 2011 (n =92), 77% female. Age from 31-87 years, mean 60 (SD=12). Patients’ likelihood of enrolling in a CT significantly increased post video [OR 9.67 , 95% CI: 2.99-49.59 (46% pre and 74% post-test), McNemar’s χ2 = 21.13, p <0.001]. Stuart-Maxwell tests showed significant changes in 27 of 30 attitudinal questions post video. Multivariate logistic regression analyses showed that baseline variables were not significantly associated with greater likelihood to enroll; the inclusion of these matching variables did not change the impact of the intervention (OR=9.9, p=0.001). Conclusions: These data demonstrate the overall efficacy of our video, which should have particular benefit for National Cancer Institute cooperative groups and utility in community-based settings.