A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis
2020; Massachusetts Medical Society; Volume: 383; Issue: 20 Linguagem: Inglês
10.1056/nejmoa2014320
ISSN1533-4406
Tópico(s)Meta-analysis and systematic reviews
ResumoWe conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary outcome was 30-day health status, as assessed with the European Quality of Life–5 Dimensions (EQ-5D) questionnaire (scores range from 0 to 1, with higher scores indicating better health status; noninferiority margin, 0.05 points). Secondary outcomes included appendectomy in the antibiotics group and complications through 90 days; analyses were prespecified in subgroups defined according to the presence or absence of an appendicolith.
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