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Kerriamycins A,B and C. New isotetracenone antibiotics.

1987; Oxford University Press; Volume: 51; Issue: 5 Linguagem: Inglês

10.1271/bbb1961.51.1397

1881-1280

Yoichi HAYAKAWA, Kazuyoshi ADACHI, Takafumi Iwakiri, KANJI IMAMURA, Kazuo Furihata, Haruo Seto, NOBORU OTAKE,

Marine Sponges and Natural Products

Three new antibiotics were obtained from the culture filtrate of an actinomycete identified as Streptomyces violaceolatus, and were named kerriamycins A, B and C, respectively. The structures of these kerriamycins were elucidated by NMR spectral analysis and chemical degradation, which revealed that each kerriamycin was composed of a common chromophore identified as aquayamycin and two or three mols of hexoses. The kerriamycins inhibited the growth of Gram-positive bacteria and prolonged the survival periods of mice bearing Ehrlich ascites carcinoma.