Portal de Periódicos da CAPES

Carnitine palmitoyl transferase I and the control of myocardial β -oxidation flux

2001; Portland Press; Volume: 29; Issue: 2 Linguagem: Inglês

10.1042/bst0290245

1470-8752

Simon Eaton, Koji Fukumoto, N. Paladio Duran, Agostino Pierro, Lewis Spitz, P. A. Quant, K. Bartlett,

Infectious Encephalopathies and Encephalitis

Carnitine palmitoyltransferase I is assumed to be rate limiting for β-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit β-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for β-oxidation in the heart.