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Sleep electroencephalograms in young children with autism with and without regression

2007; Wiley; Volume: 48; Issue: 7 Linguagem: Inglês

10.1111/j.1469-8749.2006.tb01323.x

1469-8749

Gillian Baird, Richard O. Robinson, Stewart Boyd, Tony Charman,

EEG and Brain-Computer Interfaces

Developmental Medicine & Child NeurologyVolume 48, Issue 7 p. 604-608 Free Access Sleep electroencephalograms in young children with autism with and without regression Gillian Baird, Corresponding Author FRCPCH, Consultant Paediatrician, Guy's Hospital, London, UK.*Correspondence to first author at Newcomen Centre, Guy's Hospital, St. Thomas' Street, London, SE1 9RT, UK.Search for more papers by this authorRichard O Robinson FRCP FRCPCH, Professor of Paediatric Neurology, Newcomen Centre, Guy's Hospital, London, UK.Search for more papers by this authorStuart Boyd MD, Consultant Neurophysiologist, Great Ormond Street Hospital for Children, London, UK.Search for more papers by this authorTony Charman PhD, Reader, Behavioural and Sciences Unit, Institute of Child Health, University College London, London, UK.Search for more papers by this author Gillian Baird, Corresponding Author FRCPCH, Consultant Paediatrician, Guy's Hospital, London, UK.*Correspondence to first author at Newcomen Centre, Guy's Hospital, St. Thomas' Street, London, SE1 9RT, UK.Search for more papers by this authorRichard O Robinson FRCP FRCPCH, Professor of Paediatric Neurology, Newcomen Centre, Guy's Hospital, London, UK.Search for more papers by this authorStuart Boyd MD, Consultant Neurophysiologist, Great Ormond Street Hospital for Children, London, UK.Search for more papers by this authorTony Charman PhD, Reader, Behavioural and Sciences Unit, Institute of Child Health, University College London, London, UK.Search for more papers by this author First published: 13 February 2007 https://doi.org/10.1111/j.1469-8749.2006.tb01323.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract A link has been postulated between regressive autism and the spectrum of epileptic encephalopathic conditions including Landau-Kleffner syndrome with the suggestion that subclinical epilepsy may be causative of regression in autism. This is an audit of investigation using sleep electroencephalograms (EEG) in 64 children (56 males, 8 females; mean age 35.6mo [SD 8.2mo]; range 18–48mo) with autism. No child had a history suggestive of epilepsy. Thirty-nine of the children presented with regressive autism and 20 of the participants showed some epileptiform abnormality. There was no significant difference in epileptiform activities in those who showed regression compared with those who did not. No child showed electrical status epilepticus with continuous spike-wave discharges in slow sleep. There was no evidence that these cases of autism with and without regression were associated with epileptic encephalopathy. The significance of epileptiform discharges without epilepsy in the sleep EEG in autism remains unknown. Citing Literature Volume48, Issue7July 2006Pages 604-608 ReferencesRelatedInformation