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Ritmo luz/oscuridad de las citocinas proinflamatorias en el infarto agudo de miocardio

2003; Elsevier BV; Volume: 56; Issue: 6 Linguagem: Inglês

10.1157/13048152

1579-2242

Alberto Domínguez Rodríguez, Pedro González, M.J. Bernalte Garcia, Alejandro de la Rosa, Manuel Vargas, Francisco Marrero,

Exercise and Physiological Responses

Determinadas citocinas proinflamatorias se han encontrado elevadas en pacientes con sindrome coronario agudo. En algunos estudios ha podido comprobarse que la distribucion de los accidentes isquemicos coronarios a lo largo del dia no es uniforme, sino que experimenta variaciones ritmicas. El objetivo de este estudio es determinar si existe un ritmo de luz/oscuridad de las citocinas proinflamatorias en los pacientes con infarto agudo de miocardio. Se incluyeron 40 pacientes con infarto agudo de miocardio y 40 controles. Se determinaron los valores de interleucina 6 y 1β en las primeras 24 h del episodio isquemico coronario agudo. Las muestras de sangre se extrajeron a las 03.00 (periodo oscuridad) y a las 10.00 h (periodo luz). Ambos grupos fueron similares en edad, sexo y factores de riesgo coronario. Las concentraciones de la interleucina 6 demostraron un ritmo luz/oscuridad significativo, tanto en los pacientes con infarto agudo de miocardio como en los controles (41,93 ± 5,90/100,39 ± 13,60 frente a 25,76 ± 4,45/52,67 ± 7,73 pg/ml). Ademas, la interleucina 6 fue significativamente mayor en los pacientes con infarto agudo de miocardio que en los controles. La interleucina 1β no demostro un ritmo luz/oscuridad. Tanto en el grupo control como en el de infarto agudo de miocardio, la interleucina 6 demostro un ritmo de luz/oscuridad. Los pacientes con infarto agudo de miocardio presentan concentraciones de interleucina 6 mas altas, secundarias a una respuesta fisiologica a la lesion tisular. El ritmo luz/oscuridad puede afectar a diferentes parametros fisiologicos y bioquimicos. The concentration of certain proinflammatory cytokines has been found to be elevated in patients with acute coronary syndrome. Many studies have shown that coronary ischemic accidents do not show a uniform distribution throughout the day, but instead exhibit rhythmic variations. The objective of this study is to determine whether there is a circadian pattern of variation in the concentrations of proinflammatory cytokines in patients with acute myocardial infarction. The sample included 40 patients with acute myocardial infarction and 40 controls. Levels of interleukin 6 and 1â were determined in the first 24 hours after the acute coronary ischemic episode. Blood samples were extracted at 3:00 a.m. (period of darkness) and at 10:00 a.m. (period of daylight). Both groups were similar in age, sex distribution, and coronary risk factors. Interleukin 6 levels showed a significant variation between daylight and nighttime concentrations in patients with acute myocardial infarction and controls (41.93 ± 5.90/100.39 ± 13.60 vs 25.76 ± 4.45/52.67 ± 7.73 pg/ml). However, interleukin 6 concentrations were higher in the acute myocardial infarction group than in the control group. Interleukin 1â concentrations did not vary between daylight and darkness. In both the control group and acute myocardial infarction group, interleukin 6 concentrations varied between daylight and darkness. Patients with acute myocardial infarction shown a higher concentration of interleukin 6 secondary to the physiological response to tissue damage. Circadian variations can affect the measurements obtained for different physiological and biochemical parameters.