Meet the First Authors
2019; Lippincott Williams & Wilkins; Volume: 124; Issue: 6 Linguagem: Inglês
10.1161/res.0000000000000266
ISSN1524-4571
AutoresLy Tu, Humbert Marc, Nee Suet,
Tópico(s)Extracellular vesicles in disease
ResumoHomeCirculation ResearchVol. 124, No. 6Meet the First Authors Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBMeet the First Authors Originally published14 Mar 2019https://doi.org/10.1161/RES.0000000000000266Circulation Research. 2019;124:818–821is related toSelective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary HypertensionMolecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured HeartDNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutationsis related toType 2 Diabetes and HypertensionDiscovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial HypertensionTalin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier FunctionSpecific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque DevelopmentNut Consumption in Relation to Cardiovascular Disease Incidence and Mortality Among Patients With Diabetes MellitusLoss of BMP-9 and Pulmonary Hypertension (p 846)Download figureDownload PowerPointDr Ly Tu is currently a Research Associate at INSERM, the French public research organization entirely dedicated to human health (unit UMR_S 999, Pulmonary Hypertension: Pathophysiology and Novel therapies, headed by Dr Marc Humbert). Ly earned his PhD in Cell Biology and Cardiovascular Research from the University Paris-Sud under the supervision of Dr Christophe Guignabert and Dr Marc Humbert. His study focused on the role of growth factors and their signaling in the acquisition and maintenance of the pro-proliferative and apoptosis-resistant phenotype of the dysfunctional endothelium in pulmonary arterial hypertension (PAH). In particular, he has highlighted the importance of the endothelial FGF-2 and p130cas signaling in PAH. Dr Tu is an expert in molecular and cellular biology, and he is now working on the cross-talk between pulmonary endothelial cells and arterial smooth muscle cells, as well as the endothelium/pericyte interactions. Recently, Ly Tu has obtained a permanent position at University Paris-Sud/ University Paris-Saclay, and his long-term goal is to become a leader in technological innovation to foster basic and applied research on PAH. Outside the laboratory, Ly enjoys playing badminton, traveling the world for new culinary experiences, and sharing good times with his family and friends (over a good glass of wine). In his spare time, he enjoys watching superhero movies that allow him to escape, such as The Alchemist. His favorite motto is, “Laughing is, and will always be, the best form of therapy.”DDR/TP53 Activation in DCM Caused by LMNA Mutations (p 856)Download figureDownload PowerPointDr Suet Nee Chen is an Instructor at the University of Colorado Denver-Anschutz Medical Campus, Division of Cardiology. Dr Chen earned her PhD in Cardiovascular Sciences from Baylor College of Medicine in Houston, Texas (mentor, Dr Ali J. Marian). Before that, she earned a BS in Chemical Engineering from Montana State University. Suet Nee was also an AHA Postdoctoral Fellowship awardee. Her research interest is focused on the molecular genetics and pathogenesis of human cardiomyopathies. Suet Nee has been perplexed by this question: Does aging cause DNA damage, or does DNA damage cause aging? Mutations in the human LMNA gene cause a group of premature aging syndromes. The identification of the missense mutation p.D300N in LMNA from a patient with unusual cardiac phenotype resembling an aged heart excited her and provided her the opportunity to address the aforementioned question. When Suet Nee is not working in the lab, she loves to travel and explore new things, meet new people, new destinations, new food, and new views. She loves to travel because it allows her to see through the world with a unique lens that challenges her perspective of “normal” life. She enjoys science fiction and animation films, and her favorite books are The Farther Adventures of Robinson Crusoe by Daniel Defoe and Solitude: A Return to the Self by Anthony Storr. Suet Nee’s favorite quote is, “In life, materials will decay over time, what is left in you is passion. I might as well take a chance and do what I love.”miR-33 Targeting of Abca1 Promotes Atherosclerosis (p 874)Download figureDownload PowerPointDr Nathan Price is an associate research scientist in Comparative Medicine at Yale University School of Medicine. Dr Price earned his BS in Biology from Carleton College. He began his research training as a post-baccalaureate fellow at the National Institute of Aging under Dr Rafael deCabo, and continued studying aging and metabolic function during his graduate work with Dr David Sinclair at Harvard University. Since joining the laboratory of Dr Fernandez-Hernando, Nate has focused on gaining new insight into how miRNAs contribute to the regulation of lipid metabolism and the development of atherosclerosis. His current work is centered on developing and improving tools for identifying and characterizing the impact of individual miRNA targets. When not working in the lab, Nate enjoys reading, playing sports, outdoor activities, and spending time with his one-year-old daughter, Madeleine. His favorite books are Endurance/The Century Trilogy (Ken Follett) and his favorite movie is The Three Amigos. Nathan believes that “it’s better to ask the right question than get the right answer.”miR-33 Targeting of Abca1 Promotes Atherosclerosis (p 874)Download figureDownload PowerPointThroughout her career, Dr Noemi Rotllan has been interested in research related to biomedicine and cell biology, with an emphasis in lipoprotein metabolism and cardiovascular diseases. Dr Rotllan earned her BS and MS in Biology from the University of Barcelona. She earned her PhD in Dr Francisco Blanco-Vaca’s laboratory in Hospital de la Santa Creu i Sant Pau in Barcelona, Spain. Then she undertook her first postdoctoral fellowship in Dr Edward Fisher’s laboratory at NYU with a Fulbright fellowship. Following that, she did a second postdoctoral position in Dr Carlos Fernández Hernando’s laboratory at NYU and Yale University, where she is now an Associate Research Scientist. Dr Rotllan is a recipient of the Scientific Development Grant award from the AHA. She had studied the role of miRNAs in regulating lipoprotein metabolism and the progression of atherosclerosis. In 2019, Noemi plans to move back to Barcelona in order to start her own laboratory, as a recipient of the prestigious Ramon y Cajal fellowship award. She considers talented and great lab mates and mentorship as crucial for scientific success. She also believes that it is important to keep balance between science and a personal life. She loves playing soccer, and climbing, and thinks that going out for a concert or enjoying dinners with friends can make anyone forget a bad day in the laboratory! Her most recent favorite books are Americanah by Chimamanda Ngozi Adichie, Como la sombra que se va by Antonio Muñoz Molina and Blindness by José Saramag. Her favorite movies include E.T., Shindler’s List, Amélie, The Pianist, Trainspotting, and The Great Beauty. Her favorite motto is, “It’s your place in the world; it’s your life. Go on and do all you can with it, and make it the life you want to live,” by Mae Jemison, Astronaut.Imaging Inflammatory Monocytes and Macrophages (p 881)Download figureDownload PowerPointDr Gyu Seong Heo is a postdoctoral research associate working with Dr Yongjian Liu at Mallinckrodt Institute of Radiology (MIR), Washington University in St. Louis. Dr Heo completed his PhD in the laboratory of Dr Karen L. Wooley at Texas A&M University, where he refined his skills as a synthetic chemist while developing degradable polymeric nanostructures. His desire to apply his background in Chemistry to unmet clinical needs led him to Washington University School of Medicine. At MIR, Dr Heo has been developing novel molecular imaging probes for positron emission tomography. He is interested in the development of multifunctional theranostic systems for image-guided drug delivery in various diseases including cardiovascular disease, cancer, and infectious disease. Gyu is a father to three young children, and his favorite motto is, “work smarter, not harder,” in order to find work-life balance.Integrin Activation Regulates VE-Cadherin (p 891)Download figureDownload PowerPointFadi Pulous is a PhD candidate in the lab of Dr Brian Petrich within the Aflac Cancer and Blood Disorders Center at Emory University. Fadi immigrated to the United States from Iraq at a young age with his family and was raised in Nashville, TN. He attended Vanderbilt University, earning a BA in Molecular and Cell Biology. Although a member of the Cancer Biology program within the GDBBS program, Fadi has developed a strong affinity for vascular biology during his time in the Petrich lab and is fascinated by the integral functions of the endothelial barrier in physiological and inflammatory conditions. His dissertation work is looking at understanding the mechanistic requirements of talin-mediated integrin activation in maintaining the vascular barrier as well as its role in postnatal angiogenesis. Fadi aims to defend his thesis this year and transition to a postdoctoral fellowship in anticipation of a future as an academic scientist. Outside of the lab, Fadi enjoys playing/following soccer, amateur astronomy, watching movies, and hiking with his wife. His favorite book is Never Let Me Go, by Kazuo Ishiguro, and his favorite movie is 2001: A Space Odyssey. Fadi’s favorite motto is, “Coming up with ideas is the easiest thing on earth. Putting them down is the hardest.” Rod SerlingDietary Fats and Mortality in General Population (p 904)Download figureDownload PowerPointDr Andrew Sweatt is a physician-scientist in the Division of Pulmonary and Critical Care Medicine at Stanford University, and he is part of the multi-disciplinary adult pulmonary hypertension team. Andy was raised in Reno, NV, where, in high school, he was class salutatorian and won an individual state tennis championship. He attended the University of Connecticut on scholarship and received an honors degree in Biomedical Engineering, while also competing in Division I Athletics as a four-year starter on the Men’s tennis team. Andy earned his MD at Georgetown University, completed an internal medicine residency at the University of Colorado, and trained as a pulmonary and critical care fellow at Stanford University. Andy’s current pulmonary hypertension research focuses on inflammation as a mechanistically relevant molecular platform for the discovery of novel immune phenotypes. While avoiding reductionist analysis approaches that anchor to specific clinical features or biological pathways, he agnostically applies machine learning to deconstruct molecular heterogeneity across patients. Away from work, Andy and his wife (a gastroenterologist) are the busy parents of three adorable little ones: Tyler (age 4), Emma (almost 2), and Casey (5 months). When time allows, Andy enjoys running, hiking, reading, and family adventures in Lake Tahoe and Hawaii. His favorite book is Into the World by Jon Krakauer. His favorite movie is A Beautiful Mind and his favorite TV show is The Wire. Andy believes that “success consists of going from failure to failure without loss of enthusiasm.” Winston Churchill.Nut Intake, CVD Risk, and Mortality Among Diabetes (p 920)Download figureDownload PowerPointDr Gang Liu is currently a Research Associate in the Department of Nutrition, Harvard T.H. Chan School of Public Health. He earned his PhD, under the mentorship of Dr Xu Lin, from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences in 2015. He continued his training as a Postdoctoral Research Fellow at Harvard T.H. Chan School of Public Health, under the mentorship of Dr Qi Sun and Dr Frank B. Hu. His research interests mainly focus on exploring nutritional and lifestyle factors, as well as environmental pollutants, in relation to obesity, type 2 diabetes, and cardiovascular disease. Dr Liu is also interested in using ‘omics’ tools to understand the pathological mechanisms of cardiometabolic diseases. Outside of work, he enjoys playing basketball and spending time with family.Nut Intake, CVD Risk, and Mortality Among Diabetes (p 920)Download figureDownload PowerPointDr Marta Guasch-Ferré is a Research Scientist in the Department of Nutrition at Harvard T.H. Chan School of Public Health and Instructor of Medicine at Harvard Medical School. She earned her PhD in Nutrition and Metabolism from the Rovira i Virgili University, Spain (mentor, Dr Jordi Salas-Salvadó). She previously earned a BS and MS in Human Nutrition and Dietetics from the same university. Her research interests include the role of Mediterranean diet, nuts, olive oil, and dietary fatty acids on type 2 diabetes, cardiovascular diseases (CVD), and mortality. Her most recent work, in collaboration with Dr Geng Zong, reveals how monounsaturated fatty acids from various food sources, specifically from plant or animal sources, have different effects on mortality. She hopes that her research will provide strong scientific evidence for public health messages. Her ongoing research is focused on bringing an individualized therapeutic lifestyle approach to the clinical treatment of type 2 diabetes and related traits by integrating the impact of dietary factors and metabolomics signatures on diabetes and CVD. In the lab, she enjoys collaborating with colleagues with different backgrounds from around the globe. Outside the lab, she likes travelling, reading, cooking, and spending time with her family and friends. Her favorite book (amongst many) is El Juego del Ángel by Carlos Ruiz Zafón, and her favorite television show is How I Met Your Mother. Her favorite motto is, “If you try, you can win. If you don’t try, you have already failed.”Type 2 Diabetes and Hypertension (p 930)Download figureDownload PowerPointDr Dianjianyi Sun is currently a postdoctoral research fellow at the Department of Epidemiology in Tulane University School of Public Health and Tropical Medicine. After obtaining a BS in Medical Science at Wuhan University (China), his interest in the prevention and control of cardiometabolic diseases led him to pursue a PhD in Epidemiology and Health Statistics at Peking University. Under invaluable supervision and guidance from Dr Liming Li, Dr Wei Chen, and Dr Jun Lv, he completed his research investigating the role of DNA methylation in the development of cardiometabolic disorders using genomics and epigenomics during his PhD training. In November 2015, he joined in the lab of Dr Lu Qi at the Tulane University Obesity Research Center, who has inspired and motivated him to expand his research interests on early life factors, gene-environment interactions and multi-omics of obesity, diabetes, hypertension, and major cardiovascular diseases. He hopes to become an independent epidemiologist and scientist. “Now or never” is his favorite motto. Outside of work, Dr Sun loves traveling, reading, movies (he particularly likes The Pursuit of Happiness), and music. His favorite book is 1984. Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesSelective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary HypertensionLy Tu, et al. Circulation Research. 2019;124:846-855Type 2 Diabetes and HypertensionDianjianyi Sun, et al. Circulation Research. 2019;124:930-937Molecular Imaging Visualizes Recruitment of Inflammatory Monocytes and Macrophages to the Injured HeartGyu Seong Heo, et al. Circulation Research. 2019;124:881-890Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial HypertensionAndrew J. Sweatt, et al. Circulation Research. 2019;124:904-919DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) MutationsSuet Nee Chen, et al. Circulation Research. 2019;124:856-873Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier FunctionFadi E. Pulous, et al. Circulation Research. 2019;124:891-903Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque DevelopmentNathan L. Price, et al. Circulation Research. 2019;124:874-880Nut Consumption in Relation to Cardiovascular Disease Incidence and Mortality Among Patients With Diabetes MellitusGang Liu, et al. Circulation Research. 2019;124:920-929 March 15, 2019Vol 124, Issue 6 Advertisement Article InformationMetrics © 2019 American Heart Association, Inc.https://doi.org/10.1161/RES.0000000000000266PMID: 30870127 Originally publishedMarch 14, 2019 PDF download Advertisement
Referência(s)