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Worsening of Asthma with Systemic Corticosteroids. A Case Report and Review of Literature.

2006; Springer Science+Business Media; Volume: 21; Issue: 2 Linguagem: Inglês

10.1111/j.1525-1497.2005.02102001_4.x

1525-1497

Ankur Sheth, Savio Reddymasu, Robert B. Jackson,

Urticaria and Related Conditions

Journal of General Internal MedicineVolume 21, Issue 2 p. 196-196 Free Access Worsening of Asthma with Systemic Corticosteroids A Case Report and Review of Literature Ankur Sheth MD, MPH, Ankur Sheth MD, MPH Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this authorSavio Reddymasu MD, Savio Reddymasu MD Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this authorRobert Jackson MD, Robert Jackson MD Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this author Ankur Sheth MD, MPH, Ankur Sheth MD, MPH Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this authorSavio Reddymasu MD, Savio Reddymasu MD Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this authorRobert Jackson MD, Robert Jackson MD Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.Search for more papers by this author First published: 08 March 2006 https://doi.org/10.1111/j.1525-1497.2005.02102001_4.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Despite widespread use for treatment of asthma and allergies, glucocorticoids may cause allergic reactions, even anaphylaxis. The incidence of adverse reactions to systemic glucocorticoids is 0.3%. The most commonly reported corticosteroids causing anaphylaxis like reactions are hydrocortisone, prednisone, and methylprednisolone. Most authors agree that allergic reactions to systemic corticosteroids are possibly immunoglobulin E mediated. We report a patient with asthma, aspirin allergy, and nasal polyps who developed bronchospasm following the administration of intravenous methylprednisolone sodium succinate during an acute asthmatic attack. We discuss the differential diagnosis of worsening asthma despite adequate treatment, and suggest corticosteroid-induced bronchospasm in our patient. Corticosteroid-induced bronchospasm should be considered when asthmatics fail to improve, or frankly deteriorate with systemic corticosteroid therapy, particularly when a history of aspirin allergy is present. Teaching Point: • Know the differential diagnosis for worsening of asthma despite adequate treatment. • Consider corticosteroid-induced bronchospasm when asthmatics fail to improve, or frankly deteriorate with systemic corticosteroid therapy. • Corticosteroid-induced bronchospasm is more commonly seen in asthmatics with a history of aspirin allergy. Citing Literature Volume21, Issue2February 2006Pages 196-196 RelatedInformation