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Vitamin B-6 metabolism in the blood of young adult and senescent mice

1980; Elsevier BV; Volume: 15; Issue: 5 Linguagem: Inglês

10.1016/0531-5565(80)90054-6

1873-6815

Margaret L. Fonda, Diana K. Eggers,

Drug Transport and Resistance Mechanisms

The uptake and metabolism of vitamin B-6 by the blood cells and the distribution of the radioactive vitamin B-6 metabolites in the plasma were studied by injecting [3H]-pyridoxine in the tail vein of young adult and senescent mice, killing the mice after 15 or 30 min, and separating the B-6 metabolites by ion exchange chromatography. The blood cells of both age groups took up and metabolized the tritiated pyridoxine in essentially the same fashion. Thirty min after injection of the mice, a smaller percentage of the total radioactivity in the plasma appeared in pyridoxal-P and a larger percentage appeared in pyridoxal and pyridoxine in the senescent mice than in the young mice.