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Substrate–cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance

2000; Wiley; Volume: 44; Issue: 2 Linguagem: Inglês

10.1002/1097-4695(200008)44

1097-4695

Daniel M. Suter, Paul Forscher,

Developmental Biology and Gene Regulation

Journal of NeurobiologyVolume 44, Issue 2 p. 97-113 Substrate–cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance Daniel M. Suter, Daniel M. Suter Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Search for more papers by this authorPaul Forscher, Corresponding Author Paul Forscher [email protected] Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Search for more papers by this author Daniel M. Suter, Daniel M. Suter Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Search for more papers by this authorPaul Forscher, Corresponding Author Paul Forscher [email protected] Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520Search for more papers by this author First published: 03 August 2000 https://doi.org/10.1002/1097-4695(200008)44:2 3.0.CO;2-UCitations: 253AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Growth cones are highly motile structures at the end of neuronal processes, capable of receiving multiple types of guidance cues and transducing them into directed axonal growth. Thus, to guide the axon toward the appropriate target cell, the growth cone carries out different functions: it acts as a sensor, signal transducer, and motility device. An increasing number of molecular components that mediate axon guidance have been characterized over the past years. The vast majority of these molecules include proteins that act as guidance cues and their respective receptors. In addition, more and more signaling and cytoskeleton-associated proteins have been localized to the growth cone. Furthermore, it has become evident that growth cone motility and guidance depends on a dynamic cytoskeleton that is regulated by incoming guidance information. Current and future research in the growth cone field will be focussed on how different guidance cues transmit their signals to the cytoskeleton and change its dynamic properties to affect the rate and direction of growth cone movement. In this review, we discuss recent evidence that cell adhesion molecules can regulate growth cone motility and guidance by a mechanism of substrate–cytoskeletal coupling. © 2000 John Wiley & Sons, Inc. J Neurobiol 44: 97–113, 2000 REFERENCES Aberle H, Schwartz H, Kemler R. 1996. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 61: 514–523. 10.1002/(SICI)1097-4644(19960616)61:4 3.0.CO;2-R CASPubMedWeb of Science®Google Scholar Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P. 1998. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393: 805–809. 10.1038/31729 CASPubMedWeb of Science®Google Scholar Beckerle MC. 1998. 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