Department of Urology
2015; The Juntendo Medical Society; Volume: 61; Issue: 4 Linguagem: Inglês
10.14789/jmj.61.450
ISSN2188-2126
Autores Tópico(s)Urological Disorders and Treatments
ResumoThe research topics in our department are diverse, ranging from cancer, menʼs health, and geriatrics to hereditary kidney disease (Figure -1). Research on urological cancer outcomeIt is imperative to establish a patientsʼ database of urological cancer for appropriate evaluation and the further improvement of clinical outcomes in our department.Recently, we have completed a clinical database for bladder cancer based on more than 1000 patients at Juntendo University Hospital.Using this database, we are now attempting to identify the risk factors for progression of Japanese patients with bladder cancer.We also share this database with five prestigious Korean hospitals (Seoul National, Yonsei, Asan, Hyundai, and St. Mary) in order to achieve international collaboration in this field. Molecular genetics of circulating tumor cellsCirculating tumor cells (CTCs) are cells that are shed into the vasculature from a primary tumor and circulate in the bloodstream.They play an important role in the formation of metastasis, which is, needless to say, the major cause of cancer-related death.Recently, some research showed that CTCs are not only a prognostic marker but can also be a treatment response marker.Reproducible practical methods to detect CTCs from a variety of cancers have not been established yet.We are now striving to devise methods to capture CTCs and analyze their genetic properties, so that we can unveil a yet-to-be-discovered mechanism of metastasis.
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