Intravesical Hyaluronic Acid in the Treatment of Refractory Interstitial Cystitis
1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 1 Linguagem: Inglês
10.1016/s0022-5347(01)65933-0
ISSN1527-3792
AutoresÁlvaro Morales, Laurel Emerson, J. Curtis Nickel, Mark Lundie,
Tópico(s)Pelvic floor disorders treatments
ResumoNo AccessJournal of UrologyClinical Urology: Original Article1 Jul 1996Intravesical Hyaluronic Acid in the Treatment of Refractory Interstitial Cystitis Alvaro Morales, Laurel Emerson, J. Curtis Nickel, and Mark Lundie Alvaro MoralesAlvaro Morales More articles by this author , Laurel EmersonLaurel Emerson More articles by this author , J. Curtis NickelJ. Curtis Nickel More articles by this author , and Mark LundieMark Lundie More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65933-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Based on the assumption that interstitial cystitis results from a defective mucous lining of the bladder epithelium, we investigated the activity of hyaluronic acid in the treatment of this disease. Hyaluronic acid is an important glycosaminoglycan present in all connective tissues, including the glycosaminoglycan layer of the vesical mucosa. It exhibits a variety of pharmacological properties that enhance its appeal for the therapy of interstitial cystitis. Materials and Methods: A total of 25 patients with characteristic findings of interstitial cystitis refractory to other medical treatments participated in a trial of intravesical hyaluronic acid at a dose of 40 mg. weekly for 4 weeks and then monthly. Response to therapy was evaluated by symptom score, voiding diaries and visual analog scales. Results: An initial 56 percent positive (complete plus partial) response rate at week 4 increased to 71 percent by week 12 and response was maintained until week 20. Beyond week 24 there was a moderate decrease in the effectiveness of the medication. There was no significant toxicity attributable to hyaluronic acid in the bladder. Conclusions: The response of patients with refractory interstitial cystitis to the intravesical administration of hyaluronic acid was gratifying. In the past many therapies for interstitial cystitis which were initially considered promising failed the test of a controlled study. Such a study to determine the activity of hyaluronic acid in patients with interstitial cystitis is currently under way. References 1 : Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis). J. Urol.1991; 145: 732. Link, Google Scholar 2 : Current findings and future research avenues in the study of interstitial cystitis. Urol. Clin. N. Amer.1994; 21: 163. Google Scholar 3 : The bladder mucus (glycosaminoglycan) layer in interstitial cystitis. J. Urol.1993; 149: 716. Link, Google Scholar 4 : Scanning electron microscopic findings in interstitial cystitis. Brit. J. Urol.1989; 63: 270. Google Scholar 5 : Bladder surface glycosaminoglycans (GAGs) in interstitial cystitis. J. 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Google Scholar Department of Urology, Queen's University, Kingston, Ontario, Canada.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTAKAHASHI K, TAKEUCHI J, TAKAHASHI T, MIYAUCHI S, HORIE K and UCHIYAMA Y (2018) EFFECTS OF SODIUM HYALURONATE ON EPITHELIAL HEALING OF THE VESICAL MUCOSA AND VESICAL FIBROSIS IN RABBITS WITH ACETIC ACID INDUCED CYSTITISJournal of Urology, VOL. 166, NO. 2, (710-713), Online publication date: 1-Aug-2001.Riedl C and Hohlbrugger G (2018) RE: A PROSPECTIVE STUDY OF INTERSTITIAL CYSTITIS: RESULTS OF LONGITUDINAL FOLLOWUP OF THE INTERSTITIAL CYSTITIS DATA BASE COHORTJournal of Urology, VOL. 164, NO. 6, (2029-2030), Online publication date: 1-Dec-2000.PEEKER R, HAGHSHENO M, HOLMÄNG S and FALL M (2018) INTRAVESICAL BACILLUS CALMETTE-GUERIN AND DIMETHYL SULFOXIDE FOR TREATMENT OF CLASSIC AND NONULCER INTERSTITIAL CYSTITIS:: A PROSPECTIVE, RANDOMIZED DOUBLE-BLIND STUDYJournal of Urology, VOL. 164, NO. 6, (1912-1916), Online publication date: 1-Dec-2000.WEI D, POLITANO V, SELZER M and LOKESHWAR V (2018) THE ASSOCIATION OF ELEVATED URINARY TOTAL TO SULFATED GLYCOSAMINOGLYCAN RATIO AND HIGH MOLECULAR MASS HYALURONIC ACID WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 163, NO. 5, (1577-1583), Online publication date: 1-May-2000.Porru D, Campus G, Tudino D, Valdes E, Vespa A, Scarpa R and Usai E (2018) Results of Treatment of Refractory Interstitial Cystitis With Intravesical Hyaluronic AcidJournal of Urology, VOL. 161, NO. 6, (2039-2039), Online publication date: 1-Jun-1999.ERICKSON D, SHEYKHNAZARI M, ORDILLE S and BHAVANANDAN V (2018) INCREASED URINARY HYALURONIC ACID AND INTERSTITIAL CYSTITISJournal of Urology, VOL. 160, NO. 4, (1282-1284), Online publication date: 1-Oct-1998.NICKEL J, DOWNEY J, MORALES A, EMERSON L and CLARK J (2018) RELATIVE EFFICACY OF VARIOUS EXOGENOUS GLYCOSAMINOGLYCANS IN PROVIDING A BLADDER SURFACE PERMEABILITY BARRIERJournal of Urology, VOL. 160, NO. 2, (612-614), Online publication date: 1-Aug-1998. Volume 156Issue 1July 1996Page: 45-48 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Alvaro Morales More articles by this author Laurel Emerson More articles by this author J. Curtis Nickel More articles by this author Mark Lundie More articles by this author Expand All Advertisement PDF downloadLoading ...
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