Issue Highlights
2006; Lippincott Williams & Wilkins; Volume: 114; Issue: 4 Linguagem: Inglês
10.1161/circ.114.4.257
ISSN1524-4539
Tópico(s)Cardiac and Coronary Surgery Techniques
ResumoHomeCirculationVol. 114, No. 4Issue Highlights Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBIssue Highlights Originally published25 Jul 2006https://doi.org/10.1161/circ.114.4.257Circulation. 2006;114:257SURGICAL CORRECTION OF MITRAL REGURGITATION IN THE ELDERLY: OUTCOMES AND RECENT IMPROVEMENTS, by Detaint et al.With an aging population and the traditionally high risks for surgical repair of mitral regurgitation, contemporary surgical results are of great importance. In this issue of Circulation, Detaint et al analyzed the results of mitral valve surgery for mitral regurgitation in elderly patients ≧75 years old compared to patients 65–74 and <65 years of age. They found an incremental comorbidity index in the elderly. Most important, the long-term observed and expected survival rates were similar in each group. The multivariable analysis confirmed the ability of mitral valve surgery to restore life expectancy as well in the elderly as in younger patients. Current surgical practice should be able to offer mitral valve operations to these elderly, higher-risk patients with operative mortality rates around 5%; a high reliability to repair the mitral valve for degenerative pathology causing mitral regurgitation and the restoration of the life expectancy. See p 265.CLINICAL RELEVANCE OF C-REACTIVE PROTEIN DURING FOLLOW-UP OF PATIENTS WITH ACUTE CORONARY SYNDROMES IN THE AGGRASTAT-TO-ZOCOR TRIAL, by Morrow et al.The role of measuring inflammatory markers in the setting of acute coronary syndromes is evolving. While high sensitivity C-reactive protein (hsCRP) is the most widely studied marker, it is unknown whether the associated risk of elevated levels can be modified. In this issue of Circulation, Morrow and colleagues substantially move the field forward with their analysis of 3813 patients with acute coronary syndromes in the Aggrastat-to-Zocor trial. In this prospective study, they report the association of hsCRP levels with long-term risk of death and the effect of aggressive statin therapy (simvastatin) on these levels. These important data suggest that monitoring hsCRP levels at 1 and 4 months after acute coronary syndromes can provide useful prognostic information and that associated risks can be modified by statin therapy. See p 281.GLUTARALDEHYDE-FIXED BIOPROSTHETIC HEART VALVE CONDUITS CALCIFY AND FAIL FROM XENOGRAFT REJECTION, by Manji et al.Tissue valves are the most common type of prosthesis implant. Their popularity stems from ease of implementation, excellent hemodynamics, and their favorable thrombotic profile obviating the need for chronic anticoagulation. The durability of tissue and the mechanism of failure have been a major focus for basic and clinical investigation. The relative contribution of immunological rejection, biomechanical stress, and dystrophic calcification has remained unresolved. The study by Manji et al in this issue of Circulation investigates rejection of rat aortic valves and pig aortic valves placed in the descending aorta of rats, 20 days after implantation. The xenogeneric valves compared to the syngeneric valves had more inflammation, T-cell/macrophage infiltration, and higher serum antibody levels. Future biological valve designs and surface treatments should focus on the ability to reduce and modify both cellular and humoral rejection as well as the foreign body reaction to these tissue prostheses. See p 318.Visit http://circ.ahajournals.org:Clinician UpdateIntravascular Ultrasound in Cardiovascular Medicine. See p e55.Images in Cardiovascular MedicineVentricular Tachycardia: The Spectrum Continues to Broaden: Report of Naxos Disease. See p e60.Masking Inferior Infarction by Anterior Myocardial Injury. See p e62.Chest Pain and Intimal Flap Detected by Chest Computed Tomography Scans. See p e64. Download figureDownload PowerPointCorrespondenceSee p e65. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Xu J, Jiang G, Zhang L, Chen Z, Wang H, Bai M and Zeng J (2022) Successful percutaneous left atrial appendage occlusion for atrial fibrillation in a patient with mirror-image dextrocardia: a case report, BMC Cardiovascular Disorders, 10.1186/s12872-021-02369-9, 22:1, Online publication date: 1-Dec-2022. Young L, Antwi-Boasiako S, Ferrall J, Wold L, Mohler P and El Refaey M (2022) Genetic and non-genetic risk factors associated with atrial fibrillation, Life Sciences, 10.1016/j.lfs.2022.120529, 299, (120529), Online publication date: 1-Jun-2022. 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