Serotonin-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue culture
2005; Elsevier BV; Volume: 127; Issue: 1-3 Linguagem: Inglês
10.1016/j.regpep.2004.12.009
ISSN1873-1686
AutoresMárta Gálfi, Marianna Radács, Anna Juhász, Ferenc László, Árpád Molnár, Ferenc László,
Tópico(s)Stress Responses and Cortisol
ResumoThe effects of serotonin (5-hydroxytryptamine; 5-HT) on vasopressin (VP) and oxytocin (OT) secretion were studied in 13–14-day cultures of isolated rat neurohypophyseal (NH) tissue. The VP and OT contents of the supernatant were determined by radioimmunassay after a 1 or 2 h incubation. Significantly increased levels of VP and OT production were detected in the tissue culture media following 5-HT administration, depending on the 5-HT dose. The elevation of NH hormone secretion could be partially blocked by previous administration of the 5-HT antagonist ketanserin or metergoline. WAY-100635 did not influence the increased VP secretion induced by 5-HT, but the elevated OT production was prevented by WAY-100635 before 5-HT administration. The application of WAY-100635, ketanserin or metergoline, after 5-HT administration proved ineffective. The results indicate that NH hormone release is influenced directly by the serotonergic system. The serotonergic control of VP and OT secretion from the NH tissue in rats can occur at the level of the posterior pituitary.
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