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A Reactive Oxygen Species (ROS)‐Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells

2013; Wiley; Volume: 125; Issue: 27 Linguagem: Inglês

10.1002/ange.201209633

1521-3757

Min Suk Shim, Younan Xia,

Immunotherapy and Immune Responses

Stimulierte Freisetzung: Die hohe Konzentration reaktiver Sauerstoffspezies (ROS) in Prostata-Krebszellen lässt sich für den gezielten Gentransport nutzen. Ein ROS-responsives Thioketal-basiertes kationisches Polymer wurde synthetisiert, und seine Funktionalisierung mit einem krebssuchenden Peptid führte zur selektiven und verstärkten Gentransfektion in Prostata-Krebszellen (siehe Schema). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.