Portal de Periódicos da CAPES

Type 2 Diabetes

2010; American College of Physicians; Volume: 152; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-152-5-201003020-01003

1539-3704

Sandeep Vijan,

Diabetes Management and Education

In the Clinic2 March 2010Type 2 DiabetesBarbara Turner, MD, MSED, Sankey Williams, MD, Darren Taichman, MD, PhD, and Sandeep Vijan, MD, MSBarbara Turner, MD, MSEDSearch for more papers by this author, Sankey Williams, MDSearch for more papers by this author, Darren Taichman, MD, PhDSearch for more papers by this author, and Sandeep Vijan, MD, MSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-5-201003020-01003 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editor's Note: This issue of In the Clinic has been updated.Diabetes is one of the most common illnesses encountered by internists. An estimated 23.6 million persons have diabetes in the United States, and only 17.9 million of these cases have been diagnosed (1). The incidence of diabetes is increasing because of the aging and changing ethnic mix of the population and because of worsening obesity. On the basis of current trends, the prevalence of diabetes is expected to nearly double by 2030 (2). Although diabetes care is improving by many measures, complications are still common, and diabetes remains the ...References1. American Diabetes Association. Diabetes Statistics. 2007. Accessed at www.diabetes.org/diabetes-basics/diabetes-statistics/ on 20 January 2010. Google Scholar2. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53. [PMID: 15111519] Google Scholar3. American Diabetes Association. Standards of medical care in diabetes---2010. Diabetes Care. 2010;33 Suppl 1:S11-61. [PMID: 20042772] Google Scholar4. CDC Diabetes Cost-Effectiveness Study Group, Centers for Disease Control and Prevention. The cost-effectiveness of screening for type 2 diabetes. JAMA. 1998;280:1757-63. [PMID:9842951] Google Scholar5. Hofer TP, Vijan S, Hayward RA. Estimating the microvascular benefits of screening for type 2 diabetes. Int J Technol Assess Health Care. 2000; 16: 822-33.[PMID:11028137] Google Scholar6. U.S. Preventive Services Task Force. Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;148:846-54. [PMID:18519930] Google Scholar7. Hoerger TJ, Harris R, Hicks KA, et al. Screening for type 2 diabetes mellitus: a cost-effectiveness analysis. Ann Intern Med. 2004;140:689-99. [PMID:15126252] Google Scholar8. Tuomilehto J, Lindström J, Eriksson JG, et al; Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343-50. [PMID:11333990] Google Scholar9. Knowler WC, Barrett-Connor E, Fowler SE, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID:11832527] Google Scholar10. Knowler WC, Fowler SE, Hamman RF, et al; Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374:1677-86. [PMID:19878986] Google Scholar11. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20:537-44. [PMID:9096977] Google Scholar12. Chiasson JL, Josse RG, Gomis R, et al; STOP-NIDDM Trail Research Group. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002;359:2072-7. [PMID:12086760] Google Scholar13. Gerstein HC, Yusuf S, Bosch J, et al; DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368:1096-105. [PMID:16997664] Google Scholar14. American Association of Clinical Endocrinologists/American College of Endocrinology. Statement on the Use of A1c for the Diagnosis of Diabetes. Accessed at www.aace.com/pub/pdf/guidelines/AACEpositionA1cfeb2010.pdf on 4 February 2010. Google Scholar15. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837-53. [PMID:9742976] Google Scholar16. Thomas DE, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006;3:CD002968. [PMID: 16855995] Google Scholar17. Weischen LM, Bloemendal E, Nijpels G, et al. Self-monitoring of blood glucose in patients with type 2 diabetes who are not using insulin. Cochrane Database Syst Rev. 2005; 18: CD0050060. [PMID 15846742] Google Scholar18. Holman RR, Paul SK, Bethel MA, et al. Long-term follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577-89. [PMID:18784090]. Google Scholar19. Gerstein HC, Miller ME, Byington RP, et al. Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545-59. [PMID:18539917] Google Scholar20. Duckworth W, Abraira C, Moritz T, et al; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360:129-39. [PMID:19092145] Google Scholar21. Patel A, MacMahon S, Chalmers J, et al; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72. [PMID:18539916] Google Scholar22. AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract. 2007;13 Suppl 1:1-68. [PMID: 17613449] Google Scholar23. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-65. [PMID:9742977] Google Scholar24. Yki-Järvinen H, Kauppila M, Kujansuu E, et al. Comparison of insulin regimens in patients with non-insulin-dependent diabetes mellitus. N Engl J Med. 1992;327:1426-33. [PMID:1406860] Google Scholar25. Buse JB, Wolffenbuttel BH, Herman WH, et al. DURAbility of basal versus lispro mix 75/25 insulin efficacy (DURABLE) trial 24-week results: safety and efficacy of insulin lispro mix 75/25 versus insulin glargine added to oral antihyperglycemic drugs in patients with type 2 diabetes. Diabetes Care. 2009;32:1007-13. [PMID: 19336625] Google Scholar26. Hayward RA, Manning WG, Kaplan SH, et al. Starting insulin therapy in patients with type 2 diabetes: effectiveness, complications, and resource utilization. JAMA. 1997;278:1663-9. [PMID: 9388085] Google Scholar27. Yki-Järvinen H, Ryysy L, Nikkilä K, et al. Comparison of bedtime insulin regimens in patients with type 2 diabetes mellitus. A randomized, controlled trial. Ann Intern Med. 1999;130:389-96. [PMID:10068412] Google Scholar28. Sheffield CA, Kane MP, Busch RS, et al. Safety and efficacy of exenatide in combination with insulin in patients with type 2 diabetes mellitus. Endocr Pract. 2008;14:285-92. [PMID:18463034] Google Scholar29. Yoon NM, Cavaghan MK, Brunelle RL, et al. Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting. Clin Ther. 2009;31:1511-23. [PMID:19695400] Google Scholar30. Vijan S, Hayward RA. Treatment of hypertension in type 2 diabetes mellitus: blood pressure goals, choice of agents, and setting priorities in diabetes care. Ann Intern Med. 2003;138:593-602. [PMID:12667032] Google Scholar31. Snow V, Weiss KB, Mottur-Wilson C; Clinical Efficacy Subcommittee of the American College of Physicians. The evidence base for tight blood pressure control in the management of type 2 diabetes mellitus. Ann Intern Med 2003; 138: 587-92.[PMID:12667031] Google Scholar32. Holman RR, Paul SK, Bethel MA, et al. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med. 2008;359:1565-76. [PMID:18784091] Google Scholar33. Vijan S, Hayward RA; American College of Physicians. Pharmacologic lipid-lowering therapy in type 2 diabetes mellitus: background paper for the American College of Physicians. Ann Intern Med. 2004;140:650-8. [PMID:15096337] Google Scholar34. Snow V, Aronson MD, Hornbake ER, et al; Clinical Efficacy Subcommittee of the American College of Physicians. Lipid control in the management of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2004; 140: 644-9. [PMID:15096336] Google Scholar35. LaRosa JC, Grundy SM, Waters DD, et al; Treating to New Targets (TNT) Investigators. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005;352:1425-35. [PMID:15755765] Google Scholar36. Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004; 350: 1495-504. [PMID:15007110] Google Scholar37. Belch J, MacCuish A, Campbell I, et al; Prevention of Progression of Arterial Disease and Diabetes Study Group. The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease. BMJ. 2008;337:a1840. [PMID:18927173] Google Scholar38. Vijan S, Hofer TP, Hayward RA. Cost-utility analysis of screening intervals for diabetic retinopathy in patients with type 2 diabetes mellitus. JAMA. 2000;283:889-96. [PMID:10685713] Google Scholar39. Qaseem A, Vijan S, Snow V, et al; Clinical Efficacy Assessment Subcommittee of the American College of Physicians. Glycemic control and type 2 diabetes mellitus: the optimal hemoglobin A1c targets. A guidance statement from the American College of Physicians. Ann Intern Med. 2007;147:417-22. 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Diabetic Clinic in Benin City, Nigeria 2 March 2010Volume 152, Issue 5Page: ITC3-1KeywordsBlood pressureDietExerciseGlucoseHemoglobinHypertensionHypoglycemiaInsulinType 2 diabetesWeight loss ePublished: 2 March 2010 Issue Published: 2 March 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. 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