Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper‐Catalyzed Conjugate Additions of Aryl‐ and Alkylaluminum Reagents to Acyclic Trisubstituted Enones
2013; Wiley; Volume: 125; Issue: 31 Linguagem: Inglês
10.1002/ange.201304035
ISSN1521-3757
AutoresJennifer A. Dabrowski, Matthew T. Villaume, Amir H. Hoveyda,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoAngewandte ChemieVolume 125, Issue 31 p. 8314-8317 Zuschrift Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper-Catalyzed Conjugate Additions of Aryl- and Alkylaluminum Reagents to Acyclic Trisubstituted Enones† Jennifer A. Dabrowski, Jennifer A. Dabrowski Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this authorMatthew T. Villaume, Matthew T. Villaume Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this authorProf. Amir H. Hoveyda, Corresponding Author Prof. Amir H. Hoveyda [email protected] Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this author Jennifer A. Dabrowski, Jennifer A. Dabrowski Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this authorMatthew T. Villaume, Matthew T. Villaume Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this authorProf. Amir H. Hoveyda, Corresponding Author Prof. Amir H. Hoveyda [email protected] Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467 (USA)Search for more papers by this author First published: 18 June 2013 https://doi.org/10.1002/ange.201304035Citations: 9 † Financial support was provided by the NIH (GM-47480); J.A.D. is grateful for a LaMattina Graduate Fellowship. We thank E. M. Vieira for helpful suggestions. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Acyclische quartäre Zentren durch konjugierte Addition: Die ersten Beispiele katalytischer enantioselektiver konjugierter Additionen von Aryl- und Alkylgruppen zur Bildung acyclischer quartärer stereogener Zentren wurden entwickelt (siehe Schema). Die benötigten Organoaluminiumreagentien können entweder in situ aus leicht erhältlichen Organolithiumverbindungen hergestellt werden oder sind preiswert verfügbar. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description ange_201304035_sm_miscellaneous_information.pdf1.8 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1For scholarly reviews on catalytic ECA reactions and their utility in chemical synthesis, see: Google Scholar 1aS. R. Harutyunyan, T. den Hartog, K. Geurts, A. J. Minnaard, B. L. Feringa, Chem. 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