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BIBTEX RIS

NOTES/The Oncogenic Potential of an Activated Hox-2.4 Homeobox Gene in Mouse Fibroblasts

1991; Taylor & Francis; Volume: 11; Issue: 1 Linguagem: Inglês

10.1128/mcb.11.1.554-557.1991

ISSN

1098-5549

Autores

Daniel Aberdam, Varda Negreanu, Leo Sachs, Cila Blatt,

Tópico(s)

Ubiquitin and proteasome pathways

Resumo

The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.

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