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Teratoma in the Orchiectomy Specimen and Volume of Metastasis are Predictors of Retroperitoneal Teratoma in Post-Chemotherapy Nonseminomatous Testis Cancer

2002; Lippincott Williams & Wilkins; Volume: 168; Issue: 4 Part 1 Linguagem: Inglês

10.1016/s0022-5347(05)64458-8

1527-3792

Stephen D.W. Beck, Richard S. Foster, Richard Bihrle, Thomas M. Ulbright, Michael O. Koch, Gregory R. Wahle, Lawrence H. Einhorn, John P. Donohue,

Sperm and Testicular Function

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Oct 2002Teratoma in the Orchiectomy Specimen and Volume of Metastasis are Predictors of Retroperitoneal Teratoma in Post-Chemotherapy Nonseminomatous Testis Cancer Stephen D.W. Beck, Richard S. Foster, Richard Bihrle, Thomas Ulbright, Michael O. Koch, Gregory R. Wahle, Lawrence H. Einhorn, and John P. Donohue Stephen D.W. BeckStephen D.W. Beck , Richard S. FosterRichard S. Foster , Richard BihrleRichard Bihrle , Thomas UlbrightThomas Ulbright , Michael O. KochMichael O. Koch , Gregory R. WahleGregory R. Wahle , Lawrence H. EinhornLawrence H. Einhorn , and John P. DonohueJohn P. Donohue View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64458-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Patients who require post-chemotherapy retroperitoneal lymph node dissection after induction chemotherapy for metastatic testis cancer derive therapeutic benefit from resection of teratoma but resection of necrosis is not beneficial. We determine if the absence of teratoma in the orchiectomy specimen is a reliable predictor of the absence of teratoma in the retroperitoneum at post-chemotherapy retroperitoneal lymph node dissection. Materials and Methods: A retrospective review of the Indiana University testis cancer data base was performed. A total of 644 patients who underwent retroperitoneal lymph node dissection after induction chemotherapy only were selected for study. The presence or absence of teratoma in the orchiectomy specimen and volume of retroperitoneal tumor were analyzed as predictors of retroperitoneal teratoma at post-chemotherapy retroperitoneal lymph node dissection. Results: Of the patients with teratoma in the orchiectomy specimen 85.6% had an element of teratoma in the retroperitoneum, and of those without teratomatous elements in the orchiectomy specimen 48% had teratoma in the retroperitoneum (p <0.00001). Increasing volumes of retroperitoneal tumor were associated with a higher probability of discovering teratoma at post-chemotherapy retroperitoneal lymph node dissection. Conclusions: The absence of teratoma in the orchiectomy specimen does not reliably predict the absence of teratoma in the surgical specimen at post-chemotherapy retroperitoneal lymph node dissection. 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Fuentes Márquez I, Jiménez Penick F, Olivier Gómez C and Crespí Martínez F (2003) Tumores germinales de testículoMedicine - Programa de Formación Médica Continuada Acreditado, 10.1016/S0304-5412(03)71131-7, VOL. 8, NO. 115, (6169-6178), Online publication date: 1-Jan-2003. Volume 168Issue 4 Part 1October 2002Page: 1402-1404 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordstesticular neoplasmsteratoma, lymph node excisionMetricsAuthor Information Stephen D.W. Beck More articles by this author Richard S. Foster More articles by this author Richard Bihrle More articles by this author Thomas Ulbright More articles by this author Michael O. Koch More articles by this author Gregory R. Wahle More articles by this author Lawrence H. Einhorn More articles by this author John P. Donohue More articles by this author Expand All Advertisement PDF downloadLoading ...