Epididymal markers in rats exposed to the xenoestrogen p -nonylphenol: no biochemical effects at low dosages
2001; Wiley; Volume: 33; Issue: 5 Linguagem: Inglês
10.1111/j.1439-0272.2001.tb01501.x
ISSN1439-0272
AutoresM. H. Fourie, Riana Bornman, E Viljoen,
Tópico(s)Reproductive Biology and Fertility
ResumoAndrologiaVolume 33, Issue 5 p. 305-310 Epididymal markers in rats exposed to the xenoestrogen p-nonylphenol: no biochemical effects at low dosages Dr M. H. Fourie, Corresponding Author Dr M. H. Fourie Department of Urology, University of Pretoria, and the Pretoria Academic Hospital, Pretoria, South AfricaAndrology, Department of Urology, University of Pretoria, Private Bag X169, Pretoria 0001, South Africa. Tel.: + 27 12 354 1536; Fax: +27 12 329 5152; E-mail: [email protected]Search for more papers by this authorM. S. Bornman, M. S. Bornman Department of Urology, University of Pretoria, and the Pretoria Academic Hospital, Pretoria, South AfricaSearch for more papers by this authorE. Viljoen, E. Viljoen Centre for Epidemiological Research in Southern Africa, Medical Research Council, Pretoria, South AfricaSearch for more papers by this author Dr M. H. Fourie, Corresponding Author Dr M. H. Fourie Department of Urology, University of Pretoria, and the Pretoria Academic Hospital, Pretoria, South AfricaAndrology, Department of Urology, University of Pretoria, Private Bag X169, Pretoria 0001, South Africa. Tel.: + 27 12 354 1536; Fax: +27 12 329 5152; E-mail: [email protected]Search for more papers by this authorM. S. Bornman, M. S. Bornman Department of Urology, University of Pretoria, and the Pretoria Academic Hospital, Pretoria, South AfricaSearch for more papers by this authorE. Viljoen, E. Viljoen Centre for Epidemiological Research in Southern Africa, Medical Research Council, Pretoria, South AfricaSearch for more papers by this author First published: 24 April 2009 https://doi.org/10.1111/j.1439-0272.2001.tb01501.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Summary Harmful micro- and macroscopic effects of the environmental xenoestrogen p-nonylphenol (p-NP) on the male rat reproductive system have been previously reported. In our study, biochemical evidence of epididymal involvement was sought by determining epididymal marker values after exposure at levels below (5, 20 and 50 mg kg−1) and above (100, 250 and 400 mg kg−1) the 'no observed adverse effect' level (NOAEL: 50 mg kg−1 day−1). Exposure to p-NL below the NOAEL did not affect biochemical marker values. At levels above the NOAEL, biochemical markers of epididymal function were affected by the exposure of adults, and by maternal exposure (gestational and lactational periods followed by oral exposure until sexual maturity). L-carnitine was unchanged at all levels of exposure. Exposure of adult males to levels above the NOAEL resulted in higher α-glucosidase, suggesting increased epididymal secretory activity. This could upset the balance between secretory and reabsorptive function, and could alter the biochemical composition of the epididymal luminal fluid surrounding spermatocytes during the maturation process. 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