Synthesis and surfactant properties of fluoroalkylated acrylic acid co-oligomers containing dimethylsilicone segments as potential inhibitors of HIV-1
1995; Elsevier BV; Volume: 75; Issue: 2 Linguagem: Inglês
10.1016/0022-1139(95)03309-4
ISSN1873-3328
AutoresHideo Sawada, Asahi Ohashi, Masatoshi Oue, Masanori Baba, Masahiko Abe, Motohiro Mitani, Hiromitsu Nakajima,
Tópico(s)Fluorine in Organic Chemistry
ResumoNew fluoroalkylated acrylic acid co-oligomers containing dimethylsilicone segments have been prepared by the reactions of fluoroalkanoyl peroxides with acrylic acid and dimethylsilicones possessing one vinyl or one methacryloxypropyl end-group under very mild conditions. It was demonstrated that the fluorosilicone co-oligomers obtained are soluble not only in water but also in common organic solvents. Furthermore, these co-oligomers were shown to be able to reduce the surface tension of water and m-xylene effectively, and to exhibit a strong oleophobic property on their surfaces though possessing oleophilic dimethylsilicone chains. These fluorosilicone co-oligomers, especially the methacryloxypropyl- type co-oligomers were found to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) in vitro.
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