Portal de Periódicos da CAPES

Issue Information – Table of Contents

2016; Wiley; Volume: 79; Issue: 5 Linguagem: Inglês

10.1002/ana.24662

1531-8249

Roy H. Hamilton, Estefan Ia, Ruiz De Vargas, Peter S€ Or€ Os, J. Kevin Shoemaker, Vladimir Hachinski, Johan Lindqvist, Yotam Levy, Alisha Pati-Alam, Edna C. Hardeman, Paul Gregorevic, Julien Ochala, Benedetta Bodini, Mattia Veronese, Daniel Garc Ia-Lorenzo, Marco Battaglini, Émilie Poirion, Audrey Chardain, Ce Le ́orah Freeman, Maya ́line Louapre, Caroline Tchikviladze, Fre Papeix, Bernard Zalc, Catherine Lubetzki, Michel Bottlaender, Federico Turkheimer, Bruno Stankoff, Matthew Traylor, Poneh Adib‐Samii, Denise Harold, Martin Dichgans, Julie Williams, Cathryn M. Lewis, Hugh S. Markus, Athina Tzovara, Andrea O. Rossetti, Elsa Juan, Tamarah Suys, Dragana Viceic, Marco Rusca, Mauro Oddo, Marzia De, Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch‐Daiello, Xianlin Han, John Denis Fryer, Guojun Bu, Eoin P. Flanagan, Philippe Cabre, Brian Weinshenker, Jennifer L. St. Sauver, Debra J. Jacobson, Masoud Majed, Vanda A. Lennon, Claudia F. Lucchinetti, Andrew McKeon, Marcelo Matiello, Nilifur Kale, Dean M. Wingerchuk, Jay Mandrekar, Jessica Sagen, James P. Fryer, Angala Borders, Sean J. Pittock, Andrew A. Mallick, Vijeya Ganesan, Fenella J. Kirkham, Penny Fallon, Tammy Hedderly, Tony McShane, Alasdair Parker, Evangeline Wassmer, Elizabeth Wraige, Sam Amin, Hannah B Edwards, Mario Cortina‐Borja, Finbar O’Callaghan, Marina Herwerth, Reddy Kalluri, Ruchi Srivastava, Tatjana Kleele, Selin Kenet, Zsolt Illés, Doron Merkler, Jeffrey L. Bennett, Thomas Misgeld, Bernhard Hemmer, Vaishali Satpute Janve, Ciria C. Hernández, Kelienne Verdier, Ningning Hu, Robert Macdonald, Himanshu Mishra, Iryna Prots, Steven Havlicek, Zacharias Kohl, Francesc Pérez‐Brangulí, Tom Boerstler, Lukas Anneser, Georgia Minakaki, Holger Wend, Martin Hampl, Marina Leone, Martina Br€, Jochen Klucken, André Figueiredo Reis, Leah Boyer, Gerhard Schuierer, J€ Urgen Behrens, Angelika Lampert, Felix Engel, Fred H. Gage, Urgen Winkler, Beate Winner, Cristina Rosazza, Adrian Andronache, Davide Sattin, Maria Bruzzone, Giorgio Marotta, Anna Nigri, Stefania Ferraro, Davide Rossi Sebastiano, Luca Porcu, Anna Bersano, Riccardo Benti, Matilde Leonardi, Ludovico D’Incerti, Ludovico Minati, Giorgio Tasca, Mauro Monforte, P Ottaviani, Marco Pelliccioni, Roberto Frusciante, Francesco Laschena, Enzo Ricci, John Halperin, Gary Gronseth, David Gloss, Clifford Reply, Qinghua Jiang, Guiyou Liu, Gemma Tell-Mart, Joan A. Puig‐Butille, Míriam Potrony, Célia Bádenas, Montserrat Mil, Josep Malvehy, Jose ́mart, Mario Ezquerra, Rube ́n Ferna ́ndez-Santiago, Susana Puig,

A 3D model of a canonical GABA-A receptor as seen from the synaptic cleft.It is composed of five subunits, two alpha (gray), two beta (blue) and one gamma (yellow).The central pore is permeable to chloride ions when the receptor channel is activated.Mutated amino acids highlighted in orange are at the beta/alpha subunit interface and are associated with Lennox-Gastaut syndrome, whereas those highlighted in green are at the alpha/beta and gamma/beta subunit interfaces and are associated with infantile spasms.All of the mutations adversely affect GABA-A receptor function, but their pathogenic mechanisms differ.See Janve et al., pp.