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Unimolecular Micelles.

1992; Taylor & Francis; Linguagem: Inglês

10.1007/978-94-011-2492-8_10

1061-0278

George R. Newkome,

Synthesis and Properties of Aromatic Compounds

Over the past 25 years, diverse cavities within a macrocyclic framework have been created to probe all sorts of host-guest combinations with the futuristic goal of molecular recognition. These cavities have been designed with arms & legs, inner & outer functionalized coatings, small & large cavities with two- & three-dimensional frameworks, flexible & rigid superstructures, et cetera. Is the cavity necessary or would a functionalized surface or crevice offer easy ingress for reagent and egress for products? The creation of an unimolecular micelle has the advantage that the inner region is lipophilic and the surface is hydrophilic giving rise to enhanced water-solubility as well as porous enough to permit the intrusion of lipophilic reagents. Further if the inner 'void' regions or crevices have anchor points for guests or metal ions, chemical transformations may be possible within a suitable microenvironment.