Copper Metabolism in Man
1961; Massachusetts Medical Society; Volume: 265; Issue: 19 Linguagem: Inglês
10.1056/nejm196111092651907
ISSN1533-4406
AutoresS. James Adelstein, B. L. Vallee,
Tópico(s)Contact Dermatitis and Allergies
ResumoMetabolic Abnormalities in DiseaseMost of the knowledge concerning deviations of copper metabolism in human disease derives from studies of the blood and urine concentrations of this element in afflicted patients. Such studies have their obvious limitations in elucidating the mechanisms of pathogenesis. A more profound understanding of biochemical pathology may be anticipated when tissues, cells and subcellular particles, as well as body fluids, can be studied in their native states. In one condition. albinism, the basic lesion can be traced to one enzyme normally located in specific particles within a single cell type. In others, information about the biochemical . . .
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