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Paramagnetic Metal Ions in Ligand Screening: The CoII Matrix Metalloproteinase 12

2004; Wiley; Volume: 116; Issue: 17 Linguagem: Inglês

10.1002/ange.200353453

1521-3757

Ivano Bertini, Marco Fragai, Yong‐Min Lee, Claudio Luchinat, Beatrice Terni,

Signaling Pathways in Disease

Angewandte ChemieVolume 116, Issue 17 p. 2304-2306 Zuschrift Paramagnetic Metal Ions in Ligand Screening: The CoII Matrix Metalloproteinase 12† Ivano Bertini Prof., Ivano Bertini Prof. ivanobertini@cerm.unifi.it Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorMarco Fragai Dr., Marco Fragai Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorYong-Min Lee Dr., Yong-Min Lee Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorClaudio Luchinat Prof., Claudio Luchinat Prof. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorBeatrice Terni Dr., Beatrice Terni Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this author Ivano Bertini Prof., Ivano Bertini Prof. ivanobertini@cerm.unifi.it Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorMarco Fragai Dr., Marco Fragai Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorYong-Min Lee Dr., Yong-Min Lee Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorClaudio Luchinat Prof., Claudio Luchinat Prof. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this authorBeatrice Terni Dr., Beatrice Terni Dr. Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50 019 Sesto Fiorentino, Italy, Fax: (+39) 055-457-4271 Protera S.r.L. Viale delle Idee 22, 50 019, Sesto Fiorentino, ItalySearch for more papers by this author First published: 16 April 2004 https://doi.org/10.1002/ange.200353453Citations: 15 † This work was supported by the Ente Cassa di Risparmio di Firenze, the Fondo per gli investimenti della ricerca di base (MIUR; contract RBNE01TTJW), the Fondo integrativo speciale per la ricerca (MIUR), and project no. 10537/P/01 (MIUR). We thank Professor Maurizio Pellecchia for stimulating this work. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Kleinere Proteinmengen genügen mit paramagnetischem Cobalt(II) statt diamagnetischem Zink(II) in der Matrix der Metalloproteinase MMP-12 für die Suche nach schwachen bindenden Wechselwirkungen zwischen Liganden und dem aktiven Zentrum eines Metalloproteins. Die 1H-NMR-Spektroskopie liefert dann qualitative Informationen zur Orientierung des Liganden in dem katalytischen Zentrum, das das Ziel von Wirkstoffen ist (siehe Bild). Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z53453_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume116, Issue17April 19, 2004Pages 2304-2306 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation