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N-3 and n-6 fatty acids for the treatment of autoimmune diseases

2001; Wiley; Volume: 103; Issue: 6 Linguagem: Inglês

10.1002/1438-9312(200106)103

1438-9312

Andrea Belluzzi,

Inflammatory mediators and NSAID effects

European Journal of Lipid Science and TechnologyVolume 103, Issue 6 p. 399-407 Dossier N-3 and n-6 fatty acids for the treatment of autoimmune diseases Andrea Belluzzi, Corresponding Author Andrea Belluzzi [email protected] Via Vizzani, 36, 40138 Bologna, Italy. Phone: +39-051-399914, Fax: +39-051-399914Via Vizzani, 36, 40138 Bologna, Italy. Phone: +39-051-399914, Fax: +39-051-399914Search for more papers by this author Andrea Belluzzi, Corresponding Author Andrea Belluzzi [email protected] Via Vizzani, 36, 40138 Bologna, Italy. Phone: +39-051-399914, Fax: +39-051-399914Via Vizzani, 36, 40138 Bologna, Italy. Phone: +39-051-399914, Fax: +39-051-399914Search for more papers by this author First published: 18 June 2001 https://doi.org/10.1002/1438-9312(200106)103:6 3.0.CO;2-4Citations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 K.Lauritsen, L. S.Laursen, K.Bukhave, J.RaskMadsen: Inflammatory intermediaries in inflammatory bowel disease. Int. J. Colorect. Dis. 4 (1989) 75–90. 2 N.Kromann, A.Green: Epidemiological studie in the Upernavik district,Greenland:incidence of some chronic diseases 1950–1974. Acta Med. Scand. 208 (1980) 401–406. 3 A. W.Ford-Hutchinson: Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leucocytes. Nature 286 (1980) 264. 4 D. S.Rampton, C. E.Collins: Review article: thromboxanes in inflammatory bowel disease-pathogenic and therapeutic implications. Aliment Pharm. Therap. 7 (1993) 357–367. 5 T. H.Lee, R. L.Hoover, D.Williams, R. I.Sperling, J.Ravalese, B. W.Spur, D. R.Robinson, E. J.Corey, R. A.Lewis, K. F.Austen: Effect of a dietary enrichment with eicosapentaenoic acid and docosahexaenoic acids on in vitro polymorphonuclear and monocyte leukotriene generation and polymorphonuclear leukocyte function. N. Engl. J. Med. 312 (1985) 1217–1224. 6 S.Endres, R.Ghorbani, V. E.Kelly, K.Georgilis, G.Lonnemann, J. W.van der Meer, J. G.Cannon, T. S.Rogers, M. S.Klempner, P. C.Weber: The effect of dietary supplementation with n-3 fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med. 320 (1989) 265–270. 7 P. C.Calder: N-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann. Nutr. Metab. 41 (1997) 203–234. 8 S.Endres, C.von Schacky: N-3 polyunsaturated fatty acids and human cytokine synthesis. Current Opinion in Lipidology 7 (1996) 48–52. 9 D. G.Payan, M. Y. S.Wong, T.Chernov-Rogan, F. H.Valone, W. C.Pickett, V. A.Blake, W. M.Gold, E. J.Goetzl: Alterations in Human Leukocyte function induced by ingestion of eicosapenatenoic acid. J. Clin. Immunol. 6(5) (1986) 402–410. 10 D. F.Horrobin: The regulation of prostaglandin biosynthesis by the manipulation of essential fatty acid metabolism. Rev. Pure Appl. Pharmacol. Sci. 4 (1983) 339–432. 11 V. A.Ziboh, R. S.Chapikin: Biologic significance of polyunsaturated fatty acids in the skin. Arch. Dermatol. 123 (1987) 1686–1690. 12 D. G.Baker, K. A.Krakauer, G. A.Tate, M.Laposata, R. B.Zurier: Suppression of human synovial cell proliferation by dihomo-y-linolenic acid. Arthritis Rheum 32 (1989) 1273–1281. 13 D.Santoli, P. D.Phillips, T. L.Colt, R. B.Zurier: Suppression of interleukin-2 dependent human T cell growth by E-series prostaglandins (PGE) and their precursor fatty acids: evidence for a PGE-independent mechanism of inhibition by the fatty acids. J. Clin. Invest. 35 (1990) 424–432. 14 L. S.Harbige, L.Layward, M. M.Morris-Downes, D. C.Dumonde, S.Amor: The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-b1) up-regulation and increased prostaglandin E2 (PGE2) production. Clin. Exp. Immunol. 122(3) (2000) 445–452. 15 J. H.Millar, K. J.Zilkha, M. J.Langman, H. P.Wright, A. D.Smith, J.Belin, R. H.Thompson: Double-blind trial of linoleate supplementation of the diet in multiple sclerosis. Br. Med. J. 1(856) (1973) 765–768. 16 D.Bates, P. R.Fawcett, D. A.Shaw, D.Weightmann: Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis. Br. Med. J. 2(6149) (1978) 1390–1. 17 M. A.Crawford, P.Budowski, A. G.Hassam: Dietary management in multiple sclerosis. Proc. Nutr. Soc. 38(3) (1979) 373–9. 18 E. J.Field, G.Joyce: Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids. Eur. Neurol. 22(1) (1983) 78–83. 19 R. H.Dworkin, D.Bates, J. H.Millar, D. W.Paty: Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. Neurology 34(11) (1984) 1441–1445. 20 G.Fitzgerald, L. S.Harbige, A.Forti, M. A.Crawford: The effect of nutritional counselling on diet and plasma EFA statusin multiple sclerosis patients over 3 years. Hum. Nutr. Appl. Nutr. 41(5) (1987) 297–310. 21 R. L.Swank, A.Grimsgaard: Multiple sclerosis: the lipid relationship. Am. J. Clin. Nutr. 48(6) (1988) 1387–1393. 22 D.Bates: Dietary lipids and multiple sclerosis. Ups. J. Med. Sci. Suppl. 48 (1990) 173–187. 23 L. S.Harbige, R.Jones, R.Jenkins, G.Fitzgerald, A.Forti, P.Budowski: Nutritional management in multiple sclerosis with reference to experimental models. Ups. J. Med. Sci. Suppl. 48 (1990) 189–207. 24 I.Nordvik, K. M.Myhr, H.Nyland, K. S.Bjerve: Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients. Acta Neurol. Scand. 102 (2000) 143–149. 25 W. F.Clark, A.Parbtani, M. W.Huff, B.Reid, B. J.Holub, P.Falardeau: Omega-3 fatty acid dietary supplementation in systemic lupus erythematosus. Kidney Int. 36(4) (1989) 653–660. 26 G.Westberg, A.Tarkowski: Effect of MaxEPA in patients with SLE. A double-blind, crossover study. Scand. J. Rheumatol. 19(2) (1990) 137–43. 27 A. J.Walton, M. L.Snaith, M.Locniskar, A. G.Cumberland, W. J.Morrow, D. A.Isenberg: Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 50(7) (1991) 463–466. 28 UN Das: Beneficial effect of eicosapentaenoic and docosahexaenoic acid in the menagement of systemic lupus erythematosus and its relationship to the cytokine network. Prostaglandins Leukot. Essent. Fatty Acids 51(3) (1994) 207–213. 29 K. V.Hackshaw, Y.Shi, S. R.Brandwein, K.Jones, J. Y.Westcott: A pilot study of zileuton, a novel selective 5-lipoxygenase inhibitor, in patients with systemic lupus erythematosus. J. Rheumatol. 22(3) (1995) 462–468. 30 J. J.Belch, D.Ansell, R.Madhok, A.O'Dowd, R. D.Sturrock: Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Ann. Rheum. Dis. 47(2) (1988) 96–104. 31 M.Brzeski, R.Madhok, H. A.Capell: Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal antiinflammatory drugs. Br. J. Rheumatol. 30 (1991) 370–372. 32 I. T.Budiarso: Fish oil versus olive oil. Lancet 336 (1990) 1313–1314 Letter. 33 R. F.Grimble: Interaction between nutrient, proinflammatory cytokines and inflammation. Clin. Sci. 91 (1996) 121–129. 34 A.Petroni, M.Blasevich, M.Salami, N.Papini, G. F.Montedoro, C.Galli: Inhibition of platelet aggregation and eicosanoids production by phenolic components of olive oil. Thromb. Res. 78 (1995) 151–60. 35 A.Petroni, M.Blasevich, N.Papini, M.Salami, A.Sala, C.Galli: Inhibition of leukocyte leukotriene- B4 production by an olive oil-derived phenol identified by mass-spectrometry. Thromb Res 1997; 87(3): 315–322. 36 L. J.Leventhal, E. G.Boyce, R. B.Zurier: Treatment of rheumatoid arthritis with gammalinolenic acid. Ann. Intern. Med. 119 (1993) 867–873. 37 R. B.Zurier, R. G.Rossetti, E. J.Jacobson, D. M.De Marco, N. Y.Liu, J. E.Temming, B. M.White, M.Laposata: Gammalinolenic acid treatmentof rheumatoidarthritis: a randomized placebo-controlled trial. Arthritis Rheum. 39 (1996) 1808–1817. 38 D.Rothman, H.Allen, L.Herzog, A.Pilapil, C. M.Seiler, R. B.Zurier: Effects of unsaturated fatty acids on interleukin-1beta production by human monocytes. Cytokine 9(12) (1997) 1008–1012. 39 P. R.Fortin, R. A.Lew, M. H.Liang, E. A.Wright, L. A.Beckett, T. C.Chalmers, R. I.Sperling: Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J. Clin. Epidemiol. 48 (1995) 1379–90. 40 J. A.Shapiro, T. D.Koepsell, L. F.Voigt, C. E.Dugowson, M.Kestin, J. L.Nelson: Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology 7(3) (1996) 256–263. 41 G. V.Hansen, L.Nielsen, E.Kluger, M.Thysen, H.Emmerstsen, K.Stengaard-Pedersen, E. L.Hansen, B.Unger, P. W.Andersen: Nutritional status of danish rheumatoid patients and effects of a diet adjusted in energy intake, fish meal, and antioxidants. Scan. J. Rheumatol. 25(5) (1996) 325–330. 42 C. S.Lau, K. D.Morley, J. J.Belch: Effects of fish oil supplementation on non-steroidal anti-inflammatory drug requirement in patients with mild rheumatoid arthritis – a double blind placebo controlled study. Br. J. Rheumatol. 32(11) (1993) 982–989. 43 P.Geusens, C.Wouters, J.Nijs, Y.Jiang, J.Dequeker: Long-term effect of omega-3 fatty acid supplementation in active rheumatoid arthritis. A 12-month, double-blind, controlled study. Arthritis Rheum. 37(6) (1994) 824–829. 44 J. M.Kremer, D. A.Lawrence, G. F.Petrillo, L. L.Litts, P. M.Mullaly, R. I.Rynes, R. P.Stocker, N.Parhami, N. S.Greenstein, B. R.Fuchs: Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs. Clinical and immune correlates. Arthritis Rheum. 38(8) (1995) 1107–1114. 45 K. L.Faarvang, G. L.Nielsen, B. S.Thomsen, K. L.Teglbjaerg, H. H.Lervang, E. B.Schmidt, J.Dyerberg, E.Ernst: Fish oils and rheumatoid arthritis. A randomized and double blind study. Ugeskr Laeger 156(23) (1994) 3495–3498. 46 J. M.Kremer, D. A.Lawrence, W.Jubiz, R.DiGiacomo, R.Rynes, L. E.Bartholomew, M.Sherman: Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis . Clinical and immunologic effects. Arthritis Rheum. 33 (6) (1990) 810–820. 47 J. V.Donadio, E. J.Bergstralh, K. P.Offord, D. C.Spencer, K. E.Holley: A controlled trial of fish oil in IgA nephropathy. N. Engl. J. Med. 331 (1994) 1194–1199. 48 I. J.Cartwright, A. G.Pockley, J. H.Galloway, M.Greaves, F. E.Preston: The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability, and blood viscosity in healthy volunteers. Atherosclerosis 55 (1985) 267–281. 49 R.De Caterina, R.Caprioli, D.Giannessi, R.Sicari, C.Galli, G.Lazzerini, W.Bernini, L.Carr, P.Rindi: N-3 fatty acids reduce proteinuria in patients with chronic glomerular disease. Kidney Int. 44(4) (1993) 843–850. 50 T.Hamazaki, S.Tateno, H.Shishido: Eicosapentaenoic acid and IgA nephropathy. Lancet 1 (1984) 1017–1018. 51 W. M.Bennet, R. G.Walker, P.Kincaid-Smith: Treatment of IgA nephropathy with eicosapentaenoic acid (EPA): A two year prospective trial. Clin. Nephrol. 31 (1989) 128–131. 52 E. E. Petterson, S. Rekola, L. Berglund, K. G. Sundqvist, B. Angelin, U. Diczfalusy, I. Bjorkhem, J. Bergstrom: Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: a prospective, double-blind, randomized study. 53 I. K. P.Cheng, P. C. K.Chan, M. K.Chan: The effect of fish-oil dietary supplement on the progression of mesangial IgA glomerulonephritis. Nephrol. Dial. Transplant. 5 (1990) 241–246. 54 S. M.Fung, M. J.Ferril, L. L.Norton: Fish oil theraphy in IgA nephropathy. Ann. Pharmacother. 31 (1997) 112–113. 55 J. V.Donadio, R. A.Dart, J. P.Grande, E. J.Bergstralh, D. C.Spencer: Long-term treatment with fish oil reduces renal progression in patients with IgA nephrophaty (IgAN). J. Am. Soc. Nephrol. 8 (1997) 85A. 56 R. J.Hogg: A randomized, placebo controlled, multicenter trial evaluating alternate-day prednisone and fish oil supplements in young patients with IgA nephropathy. Ann. Pharmacother. 26 (1995) 792–796. 57 J. V. Donadio, E. J. Bergstralh, K. P. Offord, J. P. Grande, T. S. Larson, D. C. Spencer: A prospective comparative studyof two doses of Omacor in the treatment of patients with IgA nephropathy. In progress. 58 R.Shoda, K.Matsueda, S.Yamato, N.Umeda: Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am. J. Clin. Nutr. 63(5) (1996) 741–745. 59 A. J.Wakefield, A. M.Sawyerr, A. P.Dhillon, R. M.Pittilo, P. M.Rowles, A. A.Lewis, R. E.Pounder: Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet 1 (1989) 1057–1062. 60 K.Jaschoenek, M. R.Clemens, M.Scheurlen: Decreased responsiveness of platelets to a stable prostacyclin analogue in patients with Crohn's disease. Reversal by n-3 polyunsaturated fatty acids. Thromb. Res. 63 (1991) 667–672. 61 J. A.Vanderhoof, J. H. Y.Park, M. K.Herrington, T. E.Adrian: Effects of dietary menhaden oil mucosal adaptation after small bowel resection in rats. Gastroenterology 106 (1994) 94–9. 62 M. A.French, A. M.Parrot, E. S.Kielo, R. V.Rajotte, L. C.Wang, A. B.Thomson, M. T.Clandinin: Polyunsaturated fat in the diet may improve intestinal function in patients with CD. Biochim Biophys Acta 1360(3) (1997) 262–270. 63 T. B.McCall, D.O'Leary, J.Bloomfield, et al.: Therapeutic potential of fish oil in the treatment of ulcerative colitis. Aliment Pharmacol. Therap. 3 (1989) 415–424. 64 P.Salomon, Asher A.Kornbluth, H. D.Janowitz: Treatment of ulcerative colitis with fish oil n-3 fatty acid: an open trial. J. Clin. Gastroenterol. 12 (1990) 157–161. 65 R.Lorenz, P. C.Weber, P.Szimnau, W.Heldwein, T.Strasser, K.Loeschke: Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease- a randomized, placebo-controlled, double-blind cross-over trial. J. Int. Med. 225(Suppl) (1989): 225–232. 66 W. R.Best, J. M.Becktel, J. W.Singleton, F.Kern: Development of a Crohn's disease activity index. Gastroenterolology 70 (1976) 439–444. 67 A. B.Hawthorne, T. K.Daneshmend, C. J.Hawkey, A.Belluzzi, S. J.Everitt, G. K.Holmes, C.Malkinson, M. Z.Shaheen, J. E.Willars: Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 months randomized controlled trial. Gut 33 (1992) 922–928. 68 W. F.Stenson, D.Cort, J.Rodgers, R.Burakoff, K.DeSchryver-Kecskemeti, T. L.Gramlich, W.Beeken: Dietary supplementation with fish oil in ulcerative colitis. Ann. Intern. Med. 116 (1992) 609–614. 69 A.Aslan, G.Triadafilopoulos: Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am. J. Gastroenterol. 87 (1992) 432–437. 70 J.Matè, J.Castanos, Garcia-Samaniego, J. M.Pajares: Does dietary fish oil maintain the remission of Crohn's disease (CD): a study case control. Gastroenterol. 100 (1993) A- 228. 71 K.Loeschke, B.Ueberschaer, A.Pietsch, E.Gruber, K.Ewe, B.Wiebecke, W.Heldwein, R.Lorenz: N-3 fatty acids retard early relapse in ulcerative colitis. Dig. Dis. Sci. 41(10) (1996) 2087–2094. 72 H.Lorenz-Meyer, P.Bauer, C.Nicolay, B.Schulz, J.Purrmann, W. E.Fleig, C.Scheurlen, I.Koop, V.Pudel, L.Carr: Omega-3 fatty acids and carbohydrate diet for maintenance of remission in Crohn's disease. Scan. J. Gastroenterol. 31 (1996) 778–85. 73 C.Brignola, G.De Simone, C.Belloli, P.Iannone, A.Belluzzi, P.Gionchetti, M.Campieri, L.Barbara: Steroid treatment in active Crohn's disease: a comparison between two regimens of different duration. Aliment Pharmacol. Ther. 8 (1994) 465–68. 74 L. J.Appel, E. R.Miller, A. J.Seidler, P. K.Whelton: Does supplementation of diet with "fish oil" reduce blood pressure? A meta-analysis of controlled following coronary angioplasty. Am. J. Prev. Med. 8 (1992) 186–192. 75 G. T.O'Connors, D. J.Malenka, E. M.Olmstead, P. S.Johnson, C. H.Hennekens: A meta-analysis of randomized trials of fish oil in prevention of restenosis following coronary angioplasty. Am. J. Prev. Med. 8 (1992) 186–192. 76 U.Kunzel, S.Bertsch: Klinische Erfahrungen mit einem standardisierten Fischölkonzentrat. Feldstudie mit 3.958 hyperlipämischen Patienten in der Praxis des niedergelassenen Arztes. Fortschr. Med. 108 (1990) 437–442. 77 S.El Boustani, C.Colette, L.Monnier, B.Descomps, A.Crastes de Paulet, F.Mendy: Enteral Absorption in man of Eicosapentaenoic acid in different Chemical forms. Lipids 22 (1987) 711–714. 78 L. D.Lawson, B. G.Hughes: Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Bioch. Bioph. Res. Comm. 152 (1988) 328–335. 79 A.Belluzzi, C.Brignola, M.Campieri, E. P.Camporesi, P.Gionchetti, F.Rizzello, C.Belloli, G.De Simone, S.Boschi, M.Miglioli, L.Barbara: Effects ofa new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. Dig. Dis. Sci. 39 (1994) 2589–2594. 80 A.Belluzzi, C.Brignola, M.Campieri, A.Pera, S.Boschi, M.Miglioli: Effect of an enteric-coated fish oil preparation on relapses in Crohn's disease. N. Engl. J. Med. 334 (1996) 1557–1616. 81 C.Brignola, P.Iannone, C.Belloli, G.De Simone, L.Bassein, P.Gionchetti, A.Belluzzi, M.Campieri, L.Barbara: Prediction of relapse in patients with Crohn's disease in remission: a simplified index using laboratory tests, enhanced by clinical characteristics. Eur. J. Gastroenterol. Hepatol. 6 (1994) 955–961. 82 S. M.Greenfield, A. T.Green, J. P.Teare, A. P.Jenkins, N. A.Punchard, C. C.Ainley, R. P.Thompson: A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. Aliment Pharmacol. Ther. 7 (1993) 159–66. Citing Literature Volume103, Issue6June 2001Pages 399-407 ReferencesRelatedInformation