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Seat belts in pregnancy.

1992; BMJ; Volume: 304; Issue: 6827 Linguagem: Inglês

10.1136/bmj.304.6827.586

0959-8138

Malcolm Pearce,

Pregnancy-related medical research

of heavy and light chains were scrambled to create new, artificial antibodies not represented in the population of human B cells from which the genes were derived.At first sight this may seem to be a disadvantage, but these artificial antibodies may be more likely to recognise human "self' components, as B cells with this property are generally deleted or suppressed by the intact immune system.Many cancer "antigens" and most targets for antibody mediated immunosuppression (lymphocyte surface markers and circulating cytokines) fall into the category of self.The random combinatorial phage library may therefore be a richer source of therapeutically useful antibodies than one that faithfully reproduces the human immune system from which it was derived.Antibodies to human tumour necrosis factor and human immunoglobulin have already been fished out of the library, suggesting that the artificial pairing of antibody variable domains on phage particles really does 1 Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity.