Meet the First Author
2019; Lippincott Williams & Wilkins; Volume: 124; Issue: 8 Linguagem: Inglês
10.1161/res.0000000000000269
ISSN1524-4571
Tópico(s)Kruppel-like factors research
ResumoHomeCirculation ResearchVol. 124, No. 8Meet the First Author Free AccessIn BriefPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessIn BriefPDF/EPUBMeet the First Author Originally published11 Apr 2019https://doi.org/10.1161/RES.0000000000000269Circulation Research. 2019;124:1142–1145is related toProtective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving ProgramAssociations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort StudiesSarcTrackCDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 ExpressionMeasurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy MutationsDevelopment of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac ContractionNovel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial InjuryGenomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated CardiomyopathySarcTrack: High-Fidelity Probing of Sarcomeres (p 1172)Download figureDownload PowerPointDr Christopher Toepfer is a Sir Henry Wellcome Postdoctoral Fellow at the University of Oxford Radcliffe Department of Medicine (with Dr Hugh Watkins), and the Department of Genetics, Harvard Medical School (Drs Christine and Jonathan Seidman). Chris earned his BS in Biomedical Science from Imperial College London. He then held a Wellcome Trust/NIH PhD studentship with Dr Michael Ferenczi of Imperial College London and Dr James Sellers NHLBI, NIH. His doctoral thesis focused on the regulation of cardiac muscle and myosins by post-translational modification in health and disease. Having a strong interest in understanding the driving mechanisms in diseases of the myocardium, Chris joined the Seidman laboratories to investigate the functional consequences of mutations in hypertrophic and dilated cardiomyopathies, involving MyBPC and Myosin under a Sir Henry Wellcome Fellowship from the Wellcome Trust. His research has focused on developing models to further interrogate the mechanisms of these diseases in human tissues and iPSC-derived cardiomyocytes. When not in the lab, Chris enjoys spending time with his wife and family, cycling, hiking, and photography. His favorite books are Dune by Frank Herbert and Night Watch by Terry Pratchett. His favorite movies are Blade Runner and The Life of Brian, and his favorite motto is, “Nothing will stop you being creative more effectively as the fear of making a mistake.” John CleeseSarcTrack: High-Fidelity Probing of Sarcomeres (p 1172)Download figureDownload PowerPointDr Arun Sharma is a postdoctoral research fellow in the laboratory of Drs Christine and Jon Seidman at the Harvard Medical School. His work focuses on utilizing human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) and CRISPR/Cas9 genome editing to model congenital heart disease. He is also interested in using hiPSC-CMs to generate custom platforms for translational drug assay development. Dr Sharma received his BS from Duke University and his PhD in stem cell biology and regenerative medicine at Stanford University. At Stanford, he trained jointly in the labs of Dr Joseph Wu and Dr Sean Wu, leading projects focusing on the applications of hiPSC-CMs for in vitro modeling of cardiac diseases, such as viral myocarditis (published in Circulation Research in 2014), high-throughput drug toxicity screening for chemotherapeutic compounds, and studying basic cardiomyocyte biology. He enjoys conveying advances in translational biology to the greater scientific and nonscientific communities through public speaking and social media (Twitter @ArunSharmaPhD). Outside of the lab, he enjoys running with his wife (a cardiologist-in-training), attempting to find stargazing-friendly dark skies to satiate his love for astronomy, and failing miserably at staying warm in the winter. His favorite books are Packing for Mars, and Game of Thrones. His favorite movies are Ex Machina, The Imitation Game, and The Lord of the Rings, and his favorite motto is, “Per aspera ad astra” (through hardships to the stars).Reorganization of Lamin-Associated Domains in DCM (p 1198)Download figureDownload PowerPointDr Sirisha M. Cheedipudi is currently a postdoctoral fellow in the lab of Dr A.J. Marian at Center for Cardiovascular Genetics, University of Texas Health Science Center, Houston. She earned her PhD from the Center for Cellular and Molecular Biology, Hyderabad, India, under the supervision of Dr Jyotsna Dhawan. Her PhD work is based on identifying the functions of quiescence-induced genes in reversibly arrested myoblasts. During her graduate studies, she developed a passion for epigenetic modulation of gene regulation. Later, she worked as postdoctoral fellow at Max-Planck institute for Heart and Lung Research, Bad Nauheim, Germany, focusing on understanding the role of Isl1 in heart development. Currently, she is involved in understanding gene regulation in cardiomyopathies and hopes to unravel the epigenetic mechanisms involved in pathogenesis of cardiomyopathies. Besides research, her interests include spending time with her daughter, enjoying music, and cooking. She enjoys action thrillers, and her favorite movie series include X-Men, The Matrix, and the Bourne movies. Her favorite motto is, “Arise, awake, and stop not until the goal is achieved.”Liquid Crystal Elastomer-Assisted Cardiac Function (p e44)Download figureDownload PowerPointDr Cecilia Ferrantini was born in a small Tuscan town in 1983. She moved to Florence to complete her MD and her music education (Piano Conservatory, 2003). During medical school, she spent a semester in the Netherlands (University of Maastrich) and experienced basic science research for the first time, studying atrial fibrillation. After graduating cum laude with an MD in 2007, she obtained a PhD in Physiology from Florence University (mentor, Dr Corrado Poggesi). Between 2009 and 2011, she traveled in Europe and the US (for conferences and for fun) and started significant collaborations, including the one with the European Laboratory for nonlinear spectroscopy, crucial for the genesis of the manuscript in this issue. Despite spending a large amount of time in the lab, she also attends the weekly outpatient clinic of the Florence Cardiomyopathy Unit. Indeed, mechanical dysfunction in hypertrophic cardiomyopathy (HCM) was the core of her research during her postdoctoral period to date, with an independent grant (obtained in 2015) on atrial dilatation in HCM. With three little kids (a boy and two twin daughters) to take care of, Cecilia now works as a researcher at Florence University and recently entered the world of smart materials and artificial muscles.Liquid Crystal Elastomer-Assisted Cardiac Function (p e44)Download figureDownload PowerPointDr Josè Manuel Pioner is currently a postdoctoral fellow in the Department of Experimental and Clinical Medicine, University of Florence, Italy, working on cardiac muscle contractility and molecular mechanisms underlying genetic cardiomyopathies. He earned his MS in Medical and Pharmaceutical Biotechnology at the University of Florence and his PhD in Molecular Medicine at the University of Siena. During the PhD, he was supervised by Dr Corrado Poggesi and his lab, working on excitation-contraction coupling mechanisms in hypertrophic cardiomyopathy using biophysical methods on human or rodent myocardial preparations. He developed skills on intact cardiac muscle and myofibril mechanics. He was also a visiting PhD student at the University of Washington working with Dr Michael Regnier and his lab where he learned and applied techniques to study contractile function on induced pluripotent stem cell derived–cardiomyocytes from patients. He collaborates with many experts from which he takes inspiration every day. Outside of his studies, he enjoys playing competitive team soccer, but he also loves cooking and food. He strongly believe that a sense of teamwork and creativity are the best ingredients for moving his work onwards.Fibroblasts Protect the Remodeling Myocardium (p 1214)Download figureDownload PowerPointDr Ilaria Russo was born and raised in the historical town of Lucca (Tuscany, Italy), better known as the birthplace of the opera composer Giacomo Puccini. She earned her MSc with a major in Molecular and Functional Biology at the University of Milan-Bicocca. In 2009, she received a scholarship from the Mario Negri Institute in Milan, where she earned her PhD in Pharmacology, mentored by Dr Roberto Latini and Dr Lidia Staszewsky in the Department of Cardiovascular Research. During her PhD, Ilaria gained strong experience in echocardiography and cardiac magnetic resonance in small and large animal models. In 2014, she obtained a training grant and moved to United States, joining Dr Nikolaos Frangogiannis’s laboratory at the Albert Einstein College of Medicine where she spent four years as a Research Fellow. Here, Ilaria became interested in fibroblast biology and cardiac fibrosis, and she performed the study featured in this issue. Since February 2019, Ilaria has been a Postdoctoral Research Scientist at the Columbia University Medical Center in the laboratory of Dr Emily Tsai. Dr Russo’s main research goal is to dissect the mechanisms underlying the development of diastolic dysfunction and heart failure in patients with preserved systolic function and nonischemic cardiomyopathy. In her spare time, Ilaria enjoys New York City, where she lives with her husband. She loves traveling, discovering new restaurants, drinking coffee, and spending time with her friends. Ilaria practices Bikram Yoga and aerobics. Her motto is, “Tell me I can’t do something, I’ll do it twice.”Myofilament-Localized Calcium Dynamics in HCM (p 1228)Download figureDownload PowerPointDr Alexander Sparrow is a postdoctoral researcher in the Radcliffe Department of Medicine at the University of Oxford. He earned his BS in Biochemistry and MS in Toxicology at the University of Birmingham and completed his PhD in Developmental Biology at the University of Nottingham in 2016 (mentor, Dr Simon Welham). Alexander then joined the lab of Dr Hugh Watkins and Dr Charles Redwood at the University of Oxford where his research, funded by the British Heart Foundation, focuses on the changes in calcium handling and contractility that occur in inherited cardiomyopathies. Alexander has developed myofilament-specific calcium sensors to study subcellular calcium dynamics in hypertrophic cardiomyopathy. Besides science, he enjoys nature and wildlife photography.CDC42 Deletion Causes Brain Vascular Malformations (p 1240)Download figureDownload PowerPointDr Marco Castro studied Biochemistry in the University of Coimbra, Portugal, and earned his PhD in Biomedicine in 2018 in the laboratory of Dr Christer Betsholtz at Uppsala University, Sweden. His PhD thesis focused on signaling molecules controlling endothelial cell sprouting during blood vessel formation in the central nervous system. His most recent work reveals how CDC42 gene is implicated in cerebral vasculopathies. Currently, Marco is a postdoctoral fellow at the Max Planck Institute for Heart and Lung Research, Germany, in the laboratory of Dr Michael Potente, where he investigates the molecules and pathways that drive organ-specific specialization of blood vessels. Marco believes that understanding these processes will yield new therapies in cardiovascular medicine, and he is inspired to pursue a scientific career that aims to improve human health. He is grateful to the many mentors who have supported him along the way and let his passion for science flourish. Outside work, he loves to travel with his girlfriend, enjoys casual dinners with friends, and always tries to squeeze in some time to exercise and play guitar. Marco grew up in a small beach town in Nazaré, Portugal, a place he is particularly passionate about and returns to during summer holidays. His favorite book is Cosmos by Carl Sagan, and his favorite movie is The Untouchables. His favorite motto is, “Do your best!”PKCδ Accelerates Endothelial Regeneration (p 1253)Download figureDownload PowerPointDr Jun Ren earned his PhD from the University of Wisconsin-Madison under the mentorship of Dr Bo Liu. He earned his MS from Sun Yat-sen University, China. He was broadly trained in molecular biology, biochemistry, and pathophysiology. During his PhD studies, Jun investigated the molecular and cellular mechanisms underlying vascular injury response with an ultimate goal of developing new therapeutic strategies to treat intimal hyperplasia. His fundamental science interest focused on crosstalk between vascular smooth muscle cells and endothelial cells, adventitial fibroblasts, as well as immune cells during tissue repair. Dr Ren has been awarded an American Heart Association Predoctoral Fellowship, and after obtaining his PhD, he started his postdoctoral training at Massachusetts General Hospital studying tumor vessels. Dr Ren believes that the key to improving human health is through multidisciplinary research. His favorite book is The Lord of the Rings, and his favorite movie is The Shawshank Redemption. His favorite motto is, “The future depends on what you do today.”Monounsaturated Fatty Acids and Mortality (p 1266)Download figureDownload PowerPointDr Marta Guasch-Ferré is a Research Scientist in the Department of Nutrition at Harvard T.H. Chan School of Public Health and Instructor of Medicine at Harvard Medical School. She earned her PhD in Nutrition and Metabolism from the Rovira i Virgili University, Spain (mentor, Dr Jordi Salas-Salvadó). She previously earned a BS and MS in Human Nutrition and Dietetics from the same university. Her research interests include the role of Mediterranean diet, nuts, olive oil, and dietary fatty acids on type 2 diabetes, cardiovascular diseases (CVD), and mortality. This most recent work, in collaboration with Dr Geng Zong, reveals how monounsaturated fatty acids from various food sources, specifically from plant or animal sources, have different effects on mortality. She hopes that her research will provide strong scientific evidence for public health messages. Her ongoing research is focused on bringing an individualized therapeutic lifestyle approach to the clinical treatment of type 2 diabetes and related traits by integrating the impact of dietary factors and metabolomics signatures on diabetes and CVD. In the lab, she enjoys collaborating with colleagues with different backgrounds from around the globe. Outside the lab, she likes travelling, reading, cooking, and spending time with her family and friends. Her favorite book (amongst many) is El Juego del Ángel by Carlos Ruiz Zafón, and her favorite television show is How I Met Your Mother. Her favorite motto is, “If you try, you can win. If you don’t try, you have already failed.”Monounsaturated Fatty Acids and Mortality (p 1266)Download figureDownload PowerPointDr Geng Zong is currently a professor at the Chinese Academy of Sciences, where he earned his PhD (mentor, Dr Xu Lin). He was a Marie Curie Postdoctoral Research Fellow of European Union Framework 7, and then completed a 3.5-year postdoctoral training at Harvard T.H. Chan School of Public Health, where he worked on his most recent paper on monounsaturated fatty acids and mortality with Dr Marta Guasch-Ferré. He is an epidemiologist focusing on dietary, lifestyle, and environmental risk factors of obesity and related cardiometabolic disorders. He loves hunting for scientific questions in daily life that will have a strong public health impact. More recently, he has become interested in delivering nutrition knowledge through news media. When not at work, he keeps himself busy by taking care of his boys and cat. His favorite book is Romance of the Three Kingdoms, a 14th-century historical novel about 169–280 AD in China, and his favorite movie is the documentary Winged Migration, primarily because of the music. Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesProtective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving ProgramIlaria Russo, et al. Circulation Research. 2019;124:1214-1227Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cause-Specific Mortality in Two US Prospective Cohort StudiesMarta Guasch-Ferré, et al. Circulation Research. 2019;124:1266-1275SarcTrackChristopher N. Toepfer, et al. Circulation Research. 2019;124:1172-1183CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 ExpressionMarco Castro, et al. Circulation Research. 2019;124:1240-1252Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy MutationsAlexander J. Sparrow, et al. Circulation Research. 2019;124:1228-1239Development of Light-Responsive Liquid Crystalline Elastomers to Assist Cardiac ContractionCecilia Ferrantini, et al. Circulation Research. 2019;124:e44-e54Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial InjuryJun Ren, et al. Circulation Research. 2019;124:1253-1265Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated CardiomyopathySirisha M. Cheedipudi, et al. Circulation Research. 2019;124:1198-1213 April 12, 2019Vol 124, Issue 8 Advertisement Article InformationMetrics © 2019 American Heart Association, Inc.https://doi.org/10.1161/RES.0000000000000269PMID: 30973812 Originally publishedApril 11, 2019 PDF download Advertisement
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