Scientific Opinion on the safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate based on a dossier submitted by Ankerpoort N.V.
2015; Wiley; Volume: 13; Issue: 5 Linguagem: Inglês
10.2903/j.efsa.2015.4109
ISSN1831-4732
Tópico(s)Iron Metabolism and Disorders
ResumoEFSA JournalVolume 13, Issue 5 4109 OpinionOpen Access Scientific Opinion on the safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate based on a dossier submitted by Ankerpoort N.V. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author First published: 21 May 2015 https://doi.org/10.2903/j.efsa.2015.4109Citations: 4 Panel members: Gabriele Aquilina, Vasileios Bampidis, Maria De Lourdes Bastos, Lucio Guido Costa, Gerhard Flachowsky, Mikolaj Antoni Gralak, Christer Hogstrand, Lubomir Leng, Secundino López-Puente, Giovanna Martelli, Baltasar Mayo, Fernando Ramos, Derek Renshaw, Guido Rychen, Maria Saarela, Kristen Sejrsen, Patrick Van Beelen, Robert John Wallace and Johannes Westendorf. Correspondence: [email protected] Acknowledgement: The Panel wishes to thank the members of the Working Group on Trace Elements, including Noël Albert Dierick, Jürgen Gropp and Alberto Mantovani, for the preparatory work on this scientific opinion. Adoption date: 28 April 2015 Published date: 21 May 2015 Question number: EFSA-Q-2012-00495 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Iron from iron-containing additives is safe in feed up to a maximum content of 250 mg/day for piglets up to one week before weaning, 450 mg/kg for bovines and poultry, 500 mg/kg for ovines, 600 mg/kg for pets and 750 mg/kg for other species/categories, except horses and fish. It was not possible to derive a maximum safe iron concentration in feed for horses or fish; as a provisional measure, the current value (750 mg/kg) could be maintained. Iron from ferrous carbonate is unlikely to modify iron concentration in edible tissues/products of animal origin; therefore, no concern for consumer safety was identified resulting from the use of ferrous carbonate in animal nutrition, provided the maximum iron content in complete feedingstuffs is respected. Owing to the presence of nickel, the additive should be regarded as a dermal and respiratory sensitiser. Ferrous carbonate should be considered as irritant to skin and eyes and to the respiratory tract. The handling of this additive is considered to be a risk by inhalation. Ferrous carbonate is generally less bioavailable than ferrous sulphate; whilst for adult animals ferrous carbonate might be efficacious, it would be insufficiently bioavailable for young animals–which require a highly efficacious iron source for a rapid response in haemoglobin synthesis. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) recommends that the currently authorised maximum iron content in feed be reduced for bovines and poultry from 750 to 450 mg Fe/kg, and for pets from 1250 to 600 mg Fe/kg. The Panel proposes the name of Iron(II) carbonate (siderite) to reflect the mineral nature and variability in composition and bioavailability of the ferrous carbonates from ores. References ACGIH (American Conference of Governmental Industrial Hygienists), 2008. TLVs and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. 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