Liver Disease with Periportal Sinusoidal Dilatation
1975; Taylor & Francis; Volume: 10; Issue: 7 Linguagem: Inglês
10.1080/00365521.1975.12097034
ISSN1502-7708
Autores Tópico(s)Liver Disease and Transplantation
ResumoWinkler, K. & Poulsen, H. Liver disease with periportal sinusoidal dilatation. A possible complication to contraceptive steroids. Scand. J. Gastroent. 1975, 10, 699-704.Four women of fertile age on long-term treatment with contraceptive steroids developed moderate liver damage and hepatomegaly. The liver histology showed a conspicuous periportal sinusoidal dilatation as the only abnorm-ality. The clinical course of the liver damage was benign. The aetiology and pathogenic mechanisms of these changes, which were localized pre-dominantly to Rappaport's Zone I, are unknown. Haemodynamic studies revealed no abnormalities. The connection to possible long-term action of oestrogens and gestagens on the liver, and the relation to peliosis and benign hepatic adenomas, are discussed.
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