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Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes

2002; Springer Science+Business Media; Volume: 15; Issue: 1 Linguagem: Inglês

10.1111/j.1432-2277.2002.tb00095.x

1432-2277

Pierre Cattan, Thierry Berney, Filoména Conti, Yvon Calmus, J C Homberg, D Houssin, Olivier Soubrane,

Liver Disease Diagnosis and Treatment

Transplant InternationalVolume 15, Issue 1 p. 34-38 Free to Read Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes Pierre Cattan, Corresponding Author Pierre Cattan Service de Chirurgie Digestive, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceTel.: +33-1-42499713 Fax: +33-1-42499757Search for more papers by this authorThierry Berney, Thierry Berney Visceral and Transplant Surgery, Geneva University Hospital, 24 rue Micheli du Crest, 1205 Geneva, CP 1211, SwitzerlandSearch for more papers by this authorFilomena Conti, Filomena Conti Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorYvon Calmus, Yvon Calmus Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorJ.C. Homberg, J.C. Homberg Laboratoire Central d'Immunologie et d'Hématologie, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, FranceSearch for more papers by this authorDidier Houssin, Didier Houssin Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorOlivier Soubrane, Olivier Soubrane Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this author Pierre Cattan, Corresponding Author Pierre Cattan Service de Chirurgie Digestive, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceTel.: +33-1-42499713 Fax: +33-1-42499757Search for more papers by this authorThierry Berney, Thierry Berney Visceral and Transplant Surgery, Geneva University Hospital, 24 rue Micheli du Crest, 1205 Geneva, CP 1211, SwitzerlandSearch for more papers by this authorFilomena Conti, Filomena Conti Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorYvon Calmus, Yvon Calmus Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorJ.C. Homberg, J.C. Homberg Laboratoire Central d'Immunologie et d'Hématologie, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, 75012 Paris, FranceSearch for more papers by this authorDidier Houssin, Didier Houssin Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this authorOlivier Soubrane, Olivier Soubrane Service de Chirurgie, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, FranceSearch for more papers by this author First published: 11 March 2005 https://doi.org/10.1111/j.1432-2277.2002.tb00095.xCitations: 20AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Abstract The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child-Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post-OLT infection and rejection between the two types. The 6-year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay. 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