MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb
2016; Cell Press; Volume: 165; Issue: 4 Linguagem: Inglês
10.1016/j.cell.2016.04.056
ISSN1097-4172
AutoresChangchun Xiao, Dinis Pedro Calado, Gunther R. Galler, To‐Ha Thai, Heide Christine Patterson, Jing Wang, Nikolaus Rajewsky, Timothy P. Bender, Klaus Rajewsky,
Tópico(s)MicroRNA in disease regulation
Resumo(Cell 131, 146–159; October 5, 2007) In Figure 2C of this article, we inadvertently used an incorrect FACS plot (duplication of the FACS plot representing mir150+/− mice) in the lower-right panel representing mir150−/− mice. The corrected panel is shown below. The small differences of the percentages in two of the panels on the right are due to an updated FlowJo software. We apologize for this error and any confusion it may have caused. The conclusions of the paper are not affected. MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-MybXiao et al.CellOctober 05, 2007In BriefMiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Full-Text PDF Open Archive
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