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Fatigue in patients with colorectal cancer treated with capecitabine and oxaliplatin

2015; Volume: 2; Issue: 1 Linguagem: Inglês

10.15761/icst.1000115

2056-4546

Sá Lilian, Vettori Josiane, Moreira Lr, Leandro Miraya, Daniela Pretti da Cunha Tirapelli, Perdoná Sc, Souza Hayala, Harley Francisco de Oliveira, Santos Fabiana, Liane Rapatoni, Ribeiro Karen, Almeida Cl, Omar Féres, Rocha Jrr, Peria Fernanda, Fernanda Maris Peria, Avenida Dos Bandeirantes,

Chemotherapy-related skin toxicity

Cancer-related fatigue is characterized by feelings of extreme tiredness, which do not improve with rest and negatively affects the physical and psychosocial function of patients, significantly reducing their quality of life.The prevalence of fatigue in cancer patients undergoing chemotherapy can be as high as 90%.Colorectal cancer is one of the neoplasms with the highest incidence of cancer-related fatigue, especially among individuals older than 65 years old.To perform a comparative assessment ofcancer-related fatigue in patients with colorectal cancer during the first four cycles of chemotherapy using the CAPOX (capecitabine and oxaliplatin) regimen.From 35 individuals initially recruited, 27 responded to the FACT-F (Functional Assessment of Chronic Illness Therapy -Fatigue scale) questionnaire at the four timepoints stipulated to assess fatigue.The average age of the sample population was 61.9 (33-84) years old, and most participants were female (66.7%).Analysis of the data revealed that fatigue did not increase and that the quality of life did not decrease over the course of chemotherapy using CAPOX.Analysis of the confidence interval of the difference of the means for the qualitative variables of theFACT-F (fatigue) and FACT-G (quality of life) questionnairesrevealed that gender was the only variable that exhibited a significant correlation with fatigue, as the scores of females were correlated with greater fatigue compared with the males (p= 0.03).Fatigue did not increase in patients with colorectal cancerduring the course of the first four cycles of chemotherapy using the CAPOX regimen.The results indicated that fatigue was stronger among females compared with males.